PIK3R6

PIK3R6
Identifiers
Aliases	PIK3R6, C17orf38, HsT41028, p84 PIKAP, p87(PIKAP), p87PIKAP, phosphoinositide-3-kinase regulatory subunit 6
External IDs	OMIM: 611462; MGI: 2144613; GeneCards: PIK3R6
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,867,677 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,443,524 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; testicle; ; spleen; ; appendix; ; apex of heart; ; blood; ; gonad; ; gallbladder; ; lymph node;
	Top expressed in
	granulocyte; ; carotid body; ; renal corpuscle; ; lumbar spinal ganglion; ; bone marrow; ; Paneth cell; ; morula; ; substantia nigra; ; central gray substance of midbrain; ; nucleus of stria terminalis;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; plasma membrane; phosphatidylinositol 3-kinase complex, class IB; membrane; phosphatidylinositol 3-kinase complex;
Biological process	platelet activation; positive regulation of T cell differentiation; phosphatidylinositol phosphate biosynthetic process; regulation of phosphatidylinositol 3-kinase activity; angiogenesis; positive regulation of angiogenesis; regulation of natural killer cell mediated cytotoxicity; phosphatidylinositol 3-kinase signaling; positive regulation of MAP kinase activity; G protein-coupled receptor signaling pathway; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	146850
	104709
	ENSG00000276231
	ENSMUSG00000046207
	Q5UE93
	Q3U6Q4
	NM_001010855; NM_001290211
	NM_001004435; NM_001081566
	NP_001010855; NP_001277140
	NP_001004435; NP_001075035
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 6 (also called p87^PIKAP) is a protein that in humans is encoded by the PIK3R6 gene. The PIK3R6 protein is a regulatory subunit of phosphoinositide 3-kinase-γ (PI3Kγ), which functions as an enzyme (a lipid kinase) that is activated by membrane receptors. PIK3R6 is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils. It is also referred to as p84 and p87. Some studies have found PIK3R6 to have a role in carcinogenesis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000276231 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046207 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. 2026-08-05. Retrieved 2026-08-19.
↑ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
↑ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
↑ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000276231 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. 2026-08-05. Retrieved 2026-08-19.

[pmid16476736-6] Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.

[pmid19906996-7] Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.

[8] Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.