PJA1

PJA1

Identifiers

PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1

External IDs

OMIM: 300420; MGI: 1101765; GeneCards: PJA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L0B

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.2.27	↗	↗	↗	↗

Gene location (Human)

Chr.	X chromosome (human)

Band	Xq13.1	Start	69,160,851 bp
Band	Xq13.1	End	69,165,521 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	X C3\|X 43.38 cM	Start	98,509,340 bp
Band	X C3\|X 43.38 cM	End	98,514,879 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

corpus epididymis

ventricular zone

nucleus accumbens

middle temporal gyrus

anterior cingulate cortex

dorsolateral prefrontal cortex

prefrontal cortex

Brodmann area 9

caudate nucleus

Top expressed in

corneal stroma

CA3 field

perirhinal cortex

entorhinal cortex

Ileal epithelium

dorsomedial hypothalamic nucleus

ventromedial nucleus

paraventricular nucleus of hypothalamus

arcuate nucleus

central gray substance of midbrain

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding ubiquitin protein ligase activity transferase activity
Cellular component	cytoplasm
Biological process	protein catabolic process protein ubiquitination
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


64219


18744


ENSG00000181191


ENSMUSG00000034403


Q8NG27


O55176

RefSeq (mRNA)


NM_001032396 NM_022368 NM_145119 NM_001382775 NM_001382776


NM_001083110 NM_001290555 NM_001290556 NM_008853

RefSeq (protein)


NP_001027568 NP_071763 NP_660095 NP_001369704 NP_001369705


NP_001076579 NP_001277484 NP_001277485 NP_032879

Location (UCSC)

Chr X: 69.16 – 69.17 Mb

Chr X: 98.51 – 98.51 Mb

PubMed search

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.

Interactions

PJA1 has been shown to interact with UBE2D2 and MAGED1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000181191 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034403 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
↑ "Entrez Gene: PJA1 praja 1".
↑ Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.

Further reading

Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, et al. (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM (March 2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". The Journal of Biological Chemistry. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.