PJA2

PJA2

Identifiers

PJA2, Neurodap1, RNF131, praja ring finger ubiquitin ligase 2

External IDs

MGI: 2159342; GeneCards: PJA2

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
2.3.2.27	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 5 (human)

Band	5q21.3	Start	109,334,713 bp
Band	5q21.3	End	109,409,974 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 E1.1	Start	64,588,000 bp
Band	17\|17 E1.1	End	64,638,911 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tail of epididymis

postcentral gyrus

frontal pole

Achilles tendon

Brodmann area 46

prefrontal cortex

orbitofrontal cortex

pons

caput epididymis

superior vestibular nucleus

Top expressed in

interventricular septum

medial dorsal nucleus

dorsal striatum

temporal lobe

olfactory tubercle

globus pallidus

inferior colliculi

facial motor nucleus

Region I of hippocampus proper

nucleus accumbens

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein kinase A regulatory subunit binding ubiquitin-protein transferase activity protein kinase A catalytic subunit binding ubiquitin protein ligase activity metal ion binding transferase activity protein binding
Cellular component	Golgi membrane postsynaptic density membrane endoplasmic reticulum synapse plasma membrane cytoplasm cell junction postsynaptic membrane Golgi apparatus intermediate filament cytoskeleton endoplasmic reticulum membrane
Biological process	hippo signaling regulation of protein kinase A signaling long-term memory protein ubiquitination inflammatory response positive regulation of toll-like receptor 2 signaling pathway regulation of macrophage activation innate immune response positive regulation of JNK cascade positive regulation of p38MAPK cascade
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9867


224938


ENSG00000198961


ENSMUSG00000024083


O43164


Q80U04

RefSeq (mRNA)


NM_014819


NM_001025309 NM_144859

RefSeq (protein)


NP_055634


NP_001020480 NP_659108

Location (UCSC)

Chr 5: 109.33 – 109.41 Mb

Chr 17: 64.59 – 64.64 Mb

PubMed search

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the PJA2 gene.

Interactions

PJA2 has been shown to interact with UBE2D2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198961 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024083 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PJA2 praja 2, RING-H2 motif containing".
↑ Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.

Further reading

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakayama M, Miyake T, Gahara Y, Ohara O, Kitamura T (July 1995). "A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse". The Journal of Neuroscience. 15 (7 Pt 2): 5238–48. doi:10.1523/JNEUROSCI.15-07-05238.1995. PMC 6577874. PMID 7623148.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.