PLA2G4B

PLA2G4B
Identifiers
Aliases	PLA2G4B, HsT16992, cPLA2-beta, phospholipase A2 group IVB
External IDs	OMIM: 606088; MGI: 2384819; GeneCards: PLA2G4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BCI, 1CJY, 1RLW
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,848,147 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,873,511 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; skin of abdomen; ; skin of leg; ; vagina; ; ectocervix; ; granulocyte; ; primary visual cortex; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; apex of heart;
	Top expressed in
	esophagus; ; lip; ; lens; ; tail of embryo; ; retina; ; layer of retina; ; neural layer of retina; ; ventricular zone; ; ganglionic eminence; ; cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; phospholipase activity; calcium-dependent phospholipase A2 activity; metal ion binding; calcium-dependent phospholipid binding; hydrolase activity; phospholipase A2 activity; phospholipase A1 activity; lysophospholipase activity;
Cellular component	cytoplasm; cytosol; endosome; early endosome membrane; membrane; mitochondrial membranes; extracellular region; mitochondrion; mitochondrial inner membrane;
Biological process	phosphatidic acid biosynthetic process; phosphatidylserine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; glycerophospholipid catabolic process; lipid metabolism; lipid catabolic process; IRE1-mediated unfolded protein response; birth; phosphatidylglycerol acyl-chain remodeling; phospholipid catabolic process; phospholipid metabolic process; metabolism; inflammatory response; arachidonic acid metabolic process; phosphatidylcholine acyl-chain remodeling; calcium-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	100137049
	211429
	ENSG00000243708
	ENSMUSG00000098488
	P0C869
	P0C871
	NM_001114633
	NM_145378
	NP_001185517; NP_005081
	NP_663353
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase A₂, group IVB (cytosolic) is an enzyme that in humans is encoded by the PLA2G4B gene. In many tissues PLA2G4B forms a readthrough transcript with JMJD7, and is predicted to produce a fusion protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000243708 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000098488 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PLA2G4B phospholipase A2, group IVB (cytosolic)".

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
Underwood KW, Song C, Kriz RW, et al. (1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J. Biol. Chem. 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
Song C, Chang XJ, Bean KM, et al. (1999). "Molecular characterization of cytosolic phospholipase A2-beta". J. Biol. Chem. 274 (24): 17063–7. doi:10.1074/jbc.274.24.17063. PMID 10358058.
Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis". J. Biol. Chem. 277 (7): 5061–73. doi:10.1074/jbc.M109083200. PMID 11741884.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ghosh M, Loper R, Gelb MH, Leslie CC (2006). "Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes". J. Biol. Chem. 281 (24): 16615–24. doi:10.1074/jbc.M601770200. PMID 16617059.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243708 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000098488 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: PLA2G4B phospholipase A2, group IVB (cytosolic)".

PLA2G4B

See also

References

Further reading