PLA2R1

PLA2R1
Identifiers
Aliases	PLA2R1, CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R, phospholipase A2 receptor 1
External IDs	OMIM: 604939; MGI: 102468; GeneCards: PLA2R1
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.2 Start 159,932,006 bp End 160,062,615 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.1 Start 60,247,887 bp End 60,383,652 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland left lobe of thyroid gland Achilles tendon right lobe of thyroid gland right coronary artery popliteal artery tibial arteries olfactory zone of nasal mucosa Descending thoracic aorta skin of leg Top expressed in neural layer of retina transitional epithelium of urinary bladder molar olfactory epithelium retinal pigment epithelium decidua pineal gland umbilical cord gastrula uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase binding carbohydrate binding transmembrane signaling receptor activity signaling receptor activity Cellular component integral component of membrane extracellular region cell surface receptor complex plasma membrane membrane integral component of plasma membrane Biological process cytokine production positive regulation of DNA damage response, signal transduction by p53 class mediator endocytosis positive regulation of arachidonic acid secretion receptor-mediated endocytosis oxidative stress-induced premature senescence reactive oxygen species metabolic process replicative senescence signal transduction negative regulation of phospholipase A2 activity negative regulation of arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 22925 18779 Ensembl ENSG00000153246 ENSMUSG00000054580 UniProt Q13018 Q62028 RefSeq (mRNA) NM_001007267 NM_001195641 NM_007366 NM_008867 RefSeq (protein) NP_001007268 NP_001182570 NP_031392 NP_032893 Location (UCSC) Chr 2: 159.93 – 160.06 Mb Chr 2: 60.25 – 60.38 Mb PubMed search
Wikidata
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Secretory phospholipase A2 receptor is a protein that in humans is encoded by the PLA2R1 gene.

Clinical significance

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases.