PLEKHA8

PLEKHA8
Identifiers
Aliases	PLEKHA8, FAPP2, pleckstrin homology domain containing A8
External IDs	OMIM: 608639; MGI: 2681164; GeneCards: PLEKHA8
Gene location (Human)
Chr.	Chromosome 7 (human)
End	30,130,483 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	54,622,824 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; placenta; ; ganglionic eminence; ; mucosa of ileum; ; bone marrow cell; ; testicle; ; visceral pleura; ; gonad; ; epithelium of colon; ; parietal pleura;
	Top expressed in
	hand; ; secondary oocyte; ; zygote; ; primary oocyte; ; superior cervical ganglion; ; Gonadal ridge; ; abdominal wall; ; endocardial cushion; ; spermatocyte; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-4-phosphate binding; ceramide binding; lipid binding; glycolipid transfer activity; glycolipid binding; lipid transfer activity; ceramide 1-phosphate binding; ceramide 1-phosphate transfer activity;
Cellular component	cytoplasm; trans-Golgi network; membrane; Golgi membrane; nucleoplasm; Golgi apparatus; cytosol;
Biological process	protein transport; ER to Golgi ceramide transport; lipid transport; glycolipid transport; phosphatidylinositol biosynthetic process; intermembrane lipid transfer; ceramide transport; ceramide 1-phosphate transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84725
	231999
	ENSG00000106086
	ENSMUSG00000005225
	Q96JA3
	Q80W71
NM_001197026; NM_001197027; NM_032639; NM_001350973; NM_001350974;
	NM_001350975; NM_001363473; NM_001363474
	NM_001001335; NM_001164361
NP_001183955; NP_001183956; NP_116028; NP_001337902; NP_001337903;
	NP_001337904; NP_001350402; NP_001350403
	NP_001001335; NP_001157833
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin homology domain containing A8 is a protein that in humans is encoded by the PLEKHA8 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106086 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005225 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Pleckstrin homology domain containing A8". Retrieved 2017-06-09.

Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA (2004). "FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P". Nat. Cell Biol. 6 (5): 393–404. doi:10.1038/ncb1119. PMID 15107860. S2CID 25874412.
Vieira OV, Verkade P, Manninen A, Simons K (2005). "FAPP2 is involved in the transport of apical cargo in polarized MDCK cells". J. Cell Biol. 170 (4): 521–6. doi:10.1083/jcb.200503078. PMC 2171512. PMID 16103222.
Vieira OV, Gaus K, Verkade P, Fullekrug J, Vaz WL, Simons K (2006). "FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells". Proc. Natl. Acad. Sci. U.S.A. 103 (49): 18556–61. doi:10.1073/pnas.0608291103. PMC 1693701. PMID 17116893.
D'Angelo G, Polishchuk E, Di Tullio G, Santoro M, Di Campli A, Godi A, West G, Bielawski J, Chuang CC, van der Spoel AC, Platt FM, Hannun YA, Polishchuk R, Mattjus P, De Matteis MA (2007). "Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide". Nature. 449 (7158): 62–7. Bibcode:2007Natur.449...62D. doi:10.1038/nature06097. PMID 17687330. S2CID 4387982.
Tritz R, Hickey MJ, Lin AH, Hadwiger P, Sah DW, Neuwelt EA, Mueller BM, Kruse CA (2009). "FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis". Biochem. Biophys. Res. Commun. 383 (2): 167–71. doi:10.1016/j.bbrc.2009.03.126. PMC 3998642. PMID 19341712.
Cao X, Coskun U, Rössle M, Buschhorn SB, Grzybek M, Dafforn TR, Lenoir M, Overduin M, Simons K (2009). "Golgi protein FAPP2 tubulates membranes". Proc. Natl. Acad. Sci. U.S.A. 106 (50): 21121–5. Bibcode:2009PNAS..10621121C. doi:10.1073/pnas.0911789106. PMC 2795549. PMID 19940249.
D'Angelo G, Rega LR, De Matteis MA (2012). "Connecting vesicular transport with lipid synthesis: FAPP2". Biochim. Biophys. Acta. 1821 (8): 1089–95. doi:10.1016/j.bbalip.2012.01.003. PMC 4331668. PMID 22266015.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106086 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005225 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Pleckstrin homology domain containing A8". Retrieved 2017-06-09.

PLEKHA8

References

Further reading