PLEKHB2

PLEKHB2

Identifiers

PLEKHB2, EVT2, pleckstrin homology domain containing B2

External IDs

OMIM: 618452; MGI: 2385825; GeneCards: PLEKHB2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3AJ4, 3VIA

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q21.1	Start	131,104,847 bp
Band	2q21.1	End	131,353,709 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 B	Start	34,889,057 bp
Band	1\|1 B	End	34,918,661 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

pons

endothelial cell

superior vestibular nucleus

inferior ganglion of vagus nerve

pars compacta

Brodmann area 23

cerebellar vermis

spinal ganglia

lateral nuclear group of thalamus

pars reticulata

Top expressed in

choroid plexus of fourth ventricle

medulla oblongata

superior colliculus

medial vestibular nucleus

entorhinal cortex

perirhinal cortex

neural layer of retina

pyloric antrum

dorsal tegmental nucleus

right kidney

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding phosphatidylinositol-3,4,5-trisphosphate binding
Cellular component	membrane recycling endosome membrane endosome integral component of membrane
Biological process	regulation of cell differentiation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55041


226971


ENSG00000115762


ENSMUSG00000026123


Q96CS7


Q9QZC7

RefSeq (mRNA)

NM_001031706 NM_001100623 NM_001267062 NM_001267063 NM_001267064
NM_001267065 NM_001267066 NM_001267067 NM_001267068 NM_001309448 NM_001309450 NM_001309451 NM_001309452 NM_017958


NM_145516 NM_175421 NM_001357425

RefSeq (protein)

NP_001094093 NP_001253991 NP_001253992 NP_001253993 NP_001253994
NP_001253995 NP_001253996 NP_001253997 NP_001296377 NP_001296379 NP_001296380 NP_001296381 NP_060428 NP_001094093.1


NP_663491 NP_780630 NP_001344354

Location (UCSC)

Chr 2: 131.1 – 131.35 Mb

Chr 1: 34.89 – 34.92 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115762 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026123 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Krappa R, Nguyen A, Burrola P, Deretic D, Lemke G (May 1999). "Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes". Proc Natl Acad Sci U S A. 96 (8): 4633–8. Bibcode:1999PNAS...96.4633K. doi:10.1073/pnas.96.8.4633. PMC 16384. PMID 10200314.
↑ "Entrez Gene: PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

v t e PDB gallery
2dhi: Solution structure of the PH domain of Evectin-2 from mouse

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