PLP2

PLP2

Identifiers

PLP2, A4, A4LSB, proteolipid protein 2 (colonic epithelium-enriched), proteolipid protein 2

External IDs

OMIM: 300112; MGI: 1298382; GeneCards: PLP2

Gene location (Human)

Chr.	X chromosome (human)

Band	Xp11.23	Start	49,171,898 bp
Band	Xp11.23	End	49,175,235 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	X A1.1\|X 3.45 cM	Start	7,534,180 bp
Band	X A1.1\|X 3.45 cM	End	7,537,629 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

gingival epithelium

skin of abdomen

Descending thoracic aorta

mucosa of esophagus

skin of leg

right coronary artery

ascending aorta

nipple

popliteal artery

tibial arteries

Top expressed in

granulocyte

epidermis

cornea

corneal stroma

lactiferous gland

lip

skin of back

white adipose tissue

yolk sac

stomach

More reference expression data


More reference expression data

Gene ontology
Molecular function	ion transmembrane transporter activity protein binding chemokine binding
Cellular component	membrane endoplasmic reticulum membrane plasma membrane endoplasmic reticulum integral component of membrane
Biological process	cytokine-mediated signaling pathway chemotaxis ion transport ion transmembrane transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


5355


18824


ENSG00000102007


ENSMUSG00000031146


Q04941


Q9R1Q7

RefSeq (mRNA)


NM_002668


NM_019755

RefSeq (protein)


NP_002659 NP_002659.1


NP_062729

Location (UCSC)

Chr X: 49.17 – 49.18 Mb

Chr X: 7.53 – 7.54 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Proteolipid protein 2 is a protein that in humans is encoded by the PLP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102007 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031146 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Oliva MM, Wu TC, Yang VW (May 1993). "Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18". Arch Biochem Biophys. 302 (1): 183–192. doi:10.1006/abbi.1993.1197. PMID 8470895.
↑ Oliva MM, Cortese JF, Yang VW (Aug 1995). "Promoter regulation of a differentially expressed gene in the human colonic epithelial cell lines HT29-18 and HT29-18-C1". Gene. 159 (2): 151–157. doi:10.1016/0378-1119(95)00130-X. PMID 7622043.
↑ "Entrez Gene: PLP2 proteolipid protein 2 (colonic epithelium-enriched)".

Further reading

Breitwieser GE, McLenithan JC, Cortese JF, et al. (1997). "Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics". Am. J. Physiol. 272 (3 Pt 1): C957–65. doi:10.1152/ajpcell.1997.272.3.C957. PMID 9124532.
Fisher SE, Ciccodicola A, Tanaka K, et al. (1998). "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp" (PDF). Genomics. 45 (2): 340–347. doi:10.1006/geno.1997.4941. hdl:11858/00-001M-0000-0012-CBE6-7. PMID 9344658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang B, Nguyen M, Breckenridge DG, et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–14468. doi:10.1074/jbc.M209684200. PMID 12529377.
Lee SM, Shin H, Jang SW, et al. (2004). "PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells". Biochem. Biophys. Res. Commun. 324 (2): 768–772. Bibcode:2004BBRC..324..768L. doi:10.1016/j.bbrc.2004.09.118. PMID 15474493.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–208. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
Zhang L, Jie C, Obie C, et al. (2007). "X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation". Genome Res. 17 (5): 641–648. doi:10.1101/gr.5336307. PMC 1855181. PMID 17416750.
Stirling PC, Srayko M, Takhar KS, et al. (2007). "Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression". Mol. Biol. Cell. 18 (6): 2336–2345. doi:10.1091/mbc.E07-01-0069. PMC 1877119. PMID 17429077.

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