Plexin A1

PLXNA1

Identifiers

PLXNA1, NOV, NOVP, PLEXIN-A1, PLXN1, Plexin A1

External IDs

OMIM: 601055; MGI: 107685; GeneCards: PLXNA1

Gene location (Human)

Chr.	Chromosome 3 (human)

Band	3q21.3	Start	126,982,693 bp
Band	3q21.3	End	127,037,389 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 D1	Start	89,293,296 bp
Band	6\|6 D1	End	89,339,602 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

stromal cell of endometrium

Brodmann area 23

endothelial cell

sural nerve

gingival epithelium

Brodmann area 46

superior frontal gyrus

Region I of hippocampus proper

orbitofrontal cortex

Top expressed in

genital tubercle

tail of embryo

bronchus

lobar bronchus

lip

dentate gyrus of hippocampal formation granule cell

ascending aorta

secondary oocyte

primary visual cortex

internal carotid artery

More reference expression data


More reference expression data

Gene ontology
Molecular function	semaphorin receptor activity signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane semaphorin receptor complex extracellular exosome integral component of plasma membrane
Biological process	regulation of axon extension involved in axon guidance neuron projection extension multicellular organism development neuron projection guidance branchiomotor neuron axon guidance dichotomous subdivision of terminal units involved in salivary gland branching regulation of smooth muscle cell migration semaphorin-plexin signaling pathway signal transduction negative regulation of cell adhesion regulation of cell shape regulation of cell migration regulation of GTPase activity positive regulation of axonogenesis semaphorin-plexin signaling pathway involved in axon guidance
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


5361


18844


ENSG00000114554


ENSMUSG00000030084


Q9UIW2


P70206

RefSeq (mRNA)


NM_032242


NM_008881

RefSeq (protein)


NP_115618


NP_032907

Location (UCSC)

Chr 3: 126.98 – 127.04 Mb

Chr 6: 89.29 – 89.34 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.

Interactions

Plexin A1 has been shown to interact with AKT1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114554 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030084 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614.
↑ "Entrez Gene: PLXNA1 plexin A1".
↑ Turner, Laura J; Nicholls Sarah; Hall Alan (Aug 2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. 279 (32). United States: 33199–205. doi:10.1074/jbc.M402943200. ISSN 0021-9258. PMID 15187088.

Further reading

Takahashi T, Fournier A, Nakamura F, et al. (1999). "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors". Cell. 99 (1): 59–69. doi:10.1016/S0092-8674(00)80062-8. PMID 10520994. S2CID 18167425.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Lett. 486 (1): 68–72. doi:10.1016/S0014-5793(00)02240-7. PMID 11108845. S2CID 7914214.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain". Neuron. 29 (2): 429–39. doi:10.1016/S0896-6273(01)00216-1. PMID 11239433. S2CID 2487482.
Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". J. Neurosci. 22 (2): 471–7. doi:10.1523/JNEUROSCI.22-02-00471.2002. PMC 6758682. PMID 11784792.
Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Usui H, Taniguchi M, Yokomizo T, Shimizu T (2003). "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains". Biochem. Biophys. Res. Commun. 300 (4): 927–31. doi:10.1016/S0006-291X(02)02966-2. PMID 12559962.
Bachelder RE, Lipscomb EA, Lin X, et al. (2003). "Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells". Cancer Res. 63 (17): 5230–3. PMID 14500350.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Toyofuku T, Zhang H, Kumanogoh A, et al. (2004). "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2". Genes Dev. 18 (4): 435–47. doi:10.1101/gad.1167304. PMC 359397. PMID 14977921.
Turner LJ, Nicholls S, Hall A (2004). "The activity of the plexin-A1 receptor is regulated by Rac". J. Biol. Chem. 279 (32): 33199–205. doi:10.1074/jbc.M402943200. PMID 15187088.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.

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