Protein phosphatase methylesterase-1

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Protein phosphatase methylesterase-1
Protein phosphatase methylesterase-1
Identifiers
EC no.	3.1.1.89
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

PPME1
Identifiers
Aliases	PPME1, PME-1, protein phosphatase methylesterase 1, ABDH19
External IDs	OMIM: 611117; MGI: 1919840; GeneCards: PPME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C5V, 3C5W
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	74,254,703 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,021,514 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; middle temporal gyrus; ; Brodmann area 9; ; cerebellar cortex; ; cerebellar hemisphere; ; right frontal lobe; ; right hemisphere of cerebellum; ; anterior cingulate cortex; ; lateral nuclear group of thalamus; ; superior frontal gyrus;
	Top expressed in
	primary motor cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cingulate gyrus; ; medial dorsal nucleus; ; arcuate nucleus; ; prefrontal cortex; ; medial geniculate nucleus; ; dorsal tegmental nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase binding; carboxylic ester hydrolase activity; hydrolase activity; protein kinase binding; protein phosphatase regulator activity; cadherin binding; protein C-terminal methylesterase activity; protein methylesterase activity; protein binding;
Cellular component	nucleoplasm;
Biological process	protein demethylation; G2/M transition of mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51400
	72590
	ENSG00000214517
	ENSMUSG00000030718
	Q9Y570
	Q8BVQ5
	NM_001271593; NM_016147
	NM_028292
	NP_001258522; NP_057231
	NP_082568
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase methylesterase-1 (EC 3.1.1.89), or PME-1, is an enzyme that in humans is encoded by the PPME1 gene. The systematic enzyme name is (phosphatase 2A protein)-leucine ester acylhydrolase, and it catalyses the reaction

[phosphatase 2A protein]-leucine methyl ester + H₂O

⇌

[phosphatase 2A protein]-leucine + methanol

A key regulator of protein phosphatase 2A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000214517 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030718 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (May 1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". The Journal of Biological Chemistry. 274 (20): 14382–91. doi:10.1074/jbc.274.20.14382. PMC 3503312. PMID 10318862.
↑ Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y (April 2008). "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell. 133 (1): 154–63. doi:10.1016/j.cell.2008.02.041. PMID 18394995.

External links

Protein+phosphatase+methylesterase-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000214517 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030718 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (May 1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". The Journal of Biological Chemistry. 274 (20): 14382–91. doi:10.1074/jbc.274.20.14382. PMC 3503312. PMID 10318862.

[6] Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y (April 2008). "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell. 133 (1): 154–63. doi:10.1016/j.cell.2008.02.041. PMID 18394995.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)