Polyamine-modulated factor 1

PMF1

Identifiers

PMF1, polyamine modulated factor 1

External IDs

OMIM: 609176; MGI: 1914287; GeneCards: PMF1

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q22	Start	156,212,993 bp
Band	1q22	End	156,240,042 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3\|3 F1	Start	88,301,450 bp
Band	3\|3 F1	End	88,317,638 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

apex of heart

right lobe of thyroid gland

left lobe of thyroid gland

gastrocnemius muscle

right auricle of heart

ectocervix

skin of leg

left ventricle

granulocyte

Top expressed in

yolk sac

embryo

embryo

ventricular zone

tibiofemoral joint

blastocyst

internal carotid artery

lip

morula

epiblast

More reference expression data

n/a

Gene ontology
Molecular function	transcription coactivator activity leucine zipper domain binding protein binding
Cellular component	chromosome cytosol MIS12/MIND type complex chromosome, centromeric region nucleus kinetochore transcription regulator complex nucleoplasm Golgi apparatus intracellular membrane-bounded organelle nuclear MIS12/MIND complex
Biological process	chromosome segregation cell division cell cycle regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


11243


67037


ENSG00000160783


ENSMUSG00000028066


Q6P1K2


Q9CPV5

RefSeq (mRNA)


NM_007221 NM_001199653 NM_001199654


NM_025928 NM_001310605

RefSeq (protein)


NP_001186582 NP_001186583 NP_009152


NP_001297534 NP_080204

Location (UCSC)

Chr 1: 156.21 – 156.24 Mb

Chr 3: 88.3 – 88.32 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang Y, Devereux W, Stewart TM, Casero RA (July 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". The Journal of Biological Chemistry. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.
↑ "Entrez Gene: PMF1 polyamine-modulated factor 1".
↑ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
↑ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.

Further reading

Wang Y, Devereux W, Stewart TM, Casero RA (April 2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". The Biochemical Journal. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.
Wang Y, Devereux W, Stewart TM, Casero RA (August 2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". The Biochemical Journal. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
Kline SL, Cheeseman IM, Hori T, Fukagawa T, Desai A (April 2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". The Journal of Cell Biology. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.

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