POF1B

POF1B
Identifiers
Aliases	POF1B, POF, POF2B, premature ovarian failure, 1B, actin binding protein, POF1B actin binding protein, FLJ22792
External IDs	OMIM: 300603; MGI: 1916943; GeneCards: POF1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BH9
Gene location (Human)
Chr.	X chromosome (human)
End	85,379,717 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	111,608,348 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of leg; ; skin of abdomen; ; rectum; ; skin of thigh; ; mucosa of sigmoid colon; ; skin of hip; ; jejunal mucosa; ; gums; ; mucosa of transverse colon;
	Top expressed in
	skin of external ear; ; skin of back; ; epidermis; ; hair follicle; ; umbilical cord; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; left colon; ; epithelium of stomach; ; mucous cell of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; actin filament binding;
Cellular component	desmosome; cell junction; actin filament; adherens junction; bicellular tight junction;
Biological process	epithelial cell morphogenesis; actin filament organization; actin cytoskeleton organization; bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79983
	69693
	ENSG00000124429
	ENSMUSG00000034607
	Q8WVV4
	Q8K4L4
	NM_001307940; NM_024921
	NM_181579
	NP_001294869; NP_079197
	NP_853557
	Wikidata
View/Edit Human	View/Edit Mouse

Protein POF1B is a protein that in humans is encoded by the POF1B gene. This protein regulates the actin cytoskeleton, which is important for the organization of epithelial cells. It may have a role in the development of the ovaries.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124429 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034607 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bione S, Toniolo D (Apr 2001). "X chromosome genes and premature ovarian failure". Semin Reprod Med. 18 (1): 51–7. doi:10.1055/s-2000-13475. PMID 11299520. S2CID 46587536.
↑ "Entrez Gene: POF1B premature ovarian failure, 1B".
1 2 "Protein POF1B". UniProt consortium. Retrieved 2026-10-18.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bione S, Rizzolio F, Sala C, et al. (2005). "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B". Hum. Reprod. 19 (12): 2759–66. doi:10.1093/humrep/deh502. PMID 15459172.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Lacombe A, Lee H, Zahed L, et al. (2006). "Disruption of POF1B Binding to Nonmuscle Actin Filaments Is Associated with Premature Ovarian Failure". Am. J. Hum. Genet. 79 (1): 113–9. doi:10.1086/505406. PMC 1474115. PMID 16773570.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124429 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034607 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11299520-5] Bione S, Toniolo D (Apr 2001). "X chromosome genes and premature ovarian failure". Semin Reprod Med. 18 (1): 51–7. doi:10.1055/s-2000-13475. PMID 11299520. S2CID 46587536.

[entrez-6] "Entrez Gene: POF1B premature ovarian failure, 1B".

[uniprot-7] 1 2 "Protein POF1B". UniProt consortium. Retrieved 2026-10-18.

POF1B

See also

References

Further reading