POLDIP3

POLDIP3
Identifiers
Aliases	POLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDs	OMIM: 611520; MGI: 1921076; GeneCards: POLDIP3
Gene location (Human)
Chr.	Chromosome 22 (human)
End	42,614,962 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	83,033,585 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; left ovary; ; oocyte; ; right ovary; ; granulocyte; ; right uterine tube; ; islet of Langerhans; ; cardia; ; body of uterus;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; motor neuron; ; condyle; ; Rostral migratory stream; ; fossa; ; medial ganglionic eminence; ; ascending aorta; ; aortic valve; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; protein-containing complex binding;
Cellular component	exon-exon junction complex; transcription export complex; nucleus; nuclear speck; cytoplasm; cytosol; nucleoplasm; cytoplasmic ribonucleoprotein granule;
Biological process	poly(A)+ mRNA export from nucleus; mRNA transport; regulation of translation; positive regulation of translation; termination of RNA polymerase II transcription; mRNA 3'-end processing; RNA export from nucleus; mRNA export from nucleus; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84271
	73826
	ENSG00000100227
	ENSMUSG00000041815
	Q9BY77; Q8WUT1
	Q8BG81
	NM_001278657; NM_032311; NM_178136; NM_001363052
	NM_178627; NM_001347082
	NP_001265586; NP_115687; NP_835237; NP_001349981
	NP_001334011; NP_848742
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100227 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041815 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
1 2 "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
↑ Richardson CJ, Bröenstrup Mark, Fingar Diane C, Jülich Kristina, Ballif Bryan A, Gygi Steven, Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17). England: 1540–9. Bibcode:2004CBio...14.1540R. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. CiteSeerX 10.1.1.321.2497. doi:10.1093/dnares/8.1.1. PMID 11258795. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17): 1540–9. Bibcode:2004CBio...14.1540R. doi:10.1016/j.cub.2004.08.061. PMID 15341740.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth". FEBS J. 273 (20): 4728–41. doi:10.1111/j.1742-4658.2006.05477.x. PMID 16984396.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100227 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041815 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12522211-5] Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.

[entrez-6] 1 2 "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".

[pmid15341740-7] Richardson CJ, Bröenstrup Mark, Fingar Diane C, Jülich Kristina, Ballif Bryan A, Gygi Steven, Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17). England: 1540–9. Bibcode:2004CBio...14.1540R. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

POLDIP3

Interactions

References

Further reading