DNA polymerase nu

POLN
Identifiers
Aliases	POLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDs	OMIM: 610887; MGI: 2675617; GeneCards: POLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XVI, 4XVK, 4XVL, 4XVM
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,242,121 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,326,792 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; putamen; ; nucleus accumbens; ; right frontal lobe; ; Brodmann area 9; ; testicle; ; anterior cingulate cortex; ; left testis; ; right testis; ; cerebellar hemisphere;
	Top expressed in
	spermatocyte; ; spermatid; ; brown adipose tissue; ; seminiferous tubule; ; lens; ; lumbar subsegment of spinal cord; ; white adipose tissue; ; primary oocyte; ; zygote; ; epithelium of lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; 5'-3' exonuclease activity; protein binding; cyclin binding; DNA-directed DNA polymerase activity; nucleic acid binding;
Cellular component	cytoplasm; nucleolus; nucleoplasm; nucleus;
Biological process	cellular response to DNA damage stimulus; DNA replication; double-strand break repair via homologous recombination; DNA repair; DNA-dependent DNA replication; interstrand cross-link repair; translesion synthesis; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	353497
	272158
	ENSG00000130997
	ENSMUSG00000045102
	Q7Z5Q5
	Q7TQ07
	NM_181808
	NM_001289803; NM_001289804; NM_181857
	NP_861524
	NP_001276732; NP_001276733; NP_862905
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene. It is a family A DNA polymerase, considered to be the least effective of the polymerase enzymes. However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130997 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045102 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Polymerase (DNA directed) nu".
↑ Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.
1 2 "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase nu

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130997 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Polymerase (DNA directed) nu".

[6] Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.

[uniprot-7] 1 2 "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

DNA polymerase nu

References

Further reading

External links