POLR3D

POLR3D
Identifiers
Aliases	POLR3D, BN51T, RPC4, RPC53, TSBN51, polymerase (RNA) III subunit D, RNA polymerase III subunit D, C53
External IDs	OMIM: 187280; MGI: 1914315; GeneCards: POLR3D
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,254,601 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,680,887 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; stromal cell of endometrium; ; Achilles tendon; ; gastrocnemius muscle; ; muscle of thigh; ; islet of Langerhans; ; ventricular zone; ; ganglionic eminence; ; left testis; ; right testis;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; yolk sac; ; tail of embryo; ; ventricular zone; ; muscle of thigh; ; epiblast; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; DNA binding; chromatin binding; RNA polymerase III activity;
Cellular component	RNA polymerase III complex; nucleus; nucleoplasm; cytosol; nuclear speck;
Biological process	positive regulation of interferon-beta production; immune system process; defense response to virus; positive regulation of innate immune response; transcription by RNA polymerase III; innate immune response; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	661
	67065
	ENSG00000168495
	ENSMUSG00000000776
	P05423
	Q91WD1
	NM_001722
	NM_001164082; NM_025945
	NP_001713
	NP_001157554; NP_080221
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.

Interactions

POLR3D has been shown to interact with POLR3E.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168495 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000776 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
↑ Chong SS, Hu P, Hernandez N (Jun 2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex". J Biol Chem. 276 (23): 20727–34. doi:10.1074/jbc.M100088200. PMID 11279001.
1 2 "Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa".

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
Greco A, Ittmann M, Barletta C, et al. (1989). "Chromosomal localization of human genes required for G1 progression in mammalian cells". Genomics. 4 (3): 240–5. doi:10.1016/0888-7543(89)90326-1. PMID 2714790.
Ittmann M, Greco A, Basilico C (1988). "Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells". Mol. Cell. Biol. 7 (10): 3386–93. doi:10.1128/MCB.7.10.3386. PMC 367988. PMID 3683386.
Jackson AJ, Ittmann M, Pugh BF (1995). "The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing". Mol. Cell. Biol. 15 (1): 94–101. doi:10.1128/MCB.15.1.94. PMC 231913. PMID 7799973.
Ittmann MM (1994). "Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III". Cell Growth Differ. 5 (7): 783–8. PMID 7947392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168495 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000776 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12391170-5] 1 2 Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.

[pmid11279001-6] Chong SS, Hu P, Hernandez N (Jun 2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex". J Biol Chem. 276 (23): 20727–34. doi:10.1074/jbc.M100088200. PMID 11279001.

[entrez-7] 1 2 "Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa".

POLR3D

Interactions

References

Further reading