POU2F3

POU2F3

Identifiers

POU2F3, Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a, POU class 2 homeobox 3

External IDs

OMIM: 607394; MGI: 102565; GeneCards: POU2F3

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11q23.3	Start	120,236,640 bp
Band	11q23.3	End	120,319,945 bp

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)

Band	9 A5.1\|9 24.21 cM	Start	43,035,234 bp
Band	9 A5.1\|9 24.21 cM	End	43,121,666 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

skin of abdomen

skin of leg

skin of thigh

skin of hip

nipple

skin of arm

vulva

palpebral conjunctiva

human penis

mucosa of transverse colon

Top expressed in

lip

gastrula

Ileal epithelium

urethra

zygote

male urethra

zone of skin

skin of external ear

skin of back

embryo

More reference expression data


More reference expression data

Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleus
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II epidermis development
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


25833


18988


ENSG00000137709


ENSMUSG00000032015


Q9UKI9


P31362

RefSeq (mRNA)


NM_001244682 NM_014352


NM_011139

RefSeq (protein)


NP_001231611 NP_055167


n/a

Location (UCSC)

Chr 11: 120.24 – 120.32 Mb

Chr 9: 43.04 – 43.12 Mb

PubMed search

View/Edit Human

View/Edit Mouse

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137709 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032015 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem. 274 (37): 26399–406. doi:10.1074/jbc.274.37.26399. PMID 10473598.
↑ "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3".

Further reading

Goldsborough A, et al. (1990). "Cloning and sequencing of POU-boxes expressed in mouse testis". Nucleic Acids Res. 18 (6): 1634. doi:10.1093/nar/18.6.1634. PMC 330540. PMID 1970171.
Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11". Nucleic Acids Res. 21 (1): 127–34. doi:10.1093/nar/21.1.127. PMC 309074. PMID 8441607.
Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300". J. Biol. Chem. 276 (35): 33036–44. doi:10.1074/jbc.M103000200. PMID 11429405.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines". Oncogene. 23 (29): 5014–22. doi:10.1038/sj.onc.1207653. PMID 15077167.
Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression". Placenta. 27 (4–5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.
Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer". Oncogene. 25 (39): 5436–45. doi:10.1038/sj.onc.1209530. PMID 16607278.
Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". J. Invest. Dermatol. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.

v t e PDB gallery
1pou: THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN

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