PPFIA4

PPFIA4

Identifiers

PPFIA4, PTPRF interacting protein alpha 4

External IDs

OMIM: 603145; GeneCards: PPFIA4

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q32.1	Start	203,026,491 bp
Band	1q32.1	End	203,078,740 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cerebellar hemisphere

right hemisphere of cerebellum

cerebellar vermis

paraflocculus of cerebellum

right frontal lobe

primary visual cortex

Brodmann area 9

middle temporal gyrus

apex of heart

cingulate gyrus

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm presynaptic active zone cell surface cytosol synapse intracellular anatomical structure
Biological process	glutamate secretion neurotransmitter secretion
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8497


n/a


ENSG00000143847


n/a


O75335


n/a

RefSeq (mRNA)

NM_001304331 NM_001304332 NM_015053 NM_001393950 NM_001393951
NM_001393952 NM_001393953 NM_001393954 NM_001393955 NM_001393956 NM_001393957


n/a

RefSeq (protein)


NP_001291260 NP_001291261


n/a

Location (UCSC)

Chr 1: 203.03 – 203.08 Mb

n/a

PubMed search

n/a

View/Edit Human

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.

Interactions

PPFIA4 has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143847 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
↑ "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".
1 2 Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
↑ Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
↑ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/s0896-6273(02)00640-2. PMID 11931740. S2CID 16142847.

Further reading

Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
Katoh M, Katoh M (2004). "Identification and characterization of human PPFIA4 gene in silico". Int. J. Mol. Med. 12 (6): 1009–14. doi:10.3892/ijmm.12.6.1009. PMID 14612982.
Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

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