PPIH

PPIH

Identifiers

PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H

External IDs

OMIM: 606095; MGI: 106499; GeneCards: PPIH

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1MZW, 1QOI

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
5.2.1.8	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p34.2	Start	42,658,335 bp
Band	1p34.2	End	42,676,758 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4 D2.1\|4 55.34 cM	Start	119,157,207 bp
Band	4 D2.1\|4 55.34 cM	End	119,177,743 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

embryo

ventricular zone

ganglionic eminence

mucosa of transverse colon

granulocyte

secondary oocyte

rectum

mucosa of esophagus

olfactory zone of nasal mucosa

lymph node

Top expressed in

ventricular zone

embryo

spermatocyte

embryo

yolk sac

morula

blastocyst

spermatid

genital tubercle

zygote

More reference expression data


More reference expression data

Gene ontology
Molecular function	ribonucleoprotein complex binding isomerase activity protein binding peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding unfolded protein binding
Cellular component	cytoplasm nuclear speck U4/U6 x U5 tri-snRNP complex spliceosomal complex nucleus nucleoplasm U4/U6 snRNP
Biological process	mRNA splicing, via spliceosome mRNA processing positive regulation of viral genome replication protein folding RNA splicing protein-containing complex assembly protein peptidyl-prolyl isomerization angiogenesis protein refolding
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10465


66101


ENSG00000171960


ENSMUSG00000060288


O43447


Q9D868

RefSeq (mRNA)


NM_006347 NM_001330510


NM_001110129 NM_001110130 NM_028677

RefSeq (protein)


NP_001317439 NP_006338


NP_001103599 NP_001103600 NP_082953

Location (UCSC)

Chr 1: 42.66 – 42.68 Mb

Chr 4: 119.16 – 119.18 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171960 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060288 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
↑ Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.
1 2 "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

Further reading

Reidt U, Reuter K, Achsel T, et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin" (PDF). J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041. S2CID 20261807.
Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. hdl:11858/00-001M-0000-0012-F238-B. PMID 12875835.
Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

v t e PDB gallery
1mzw: Crystal structure of a U4/U6 snRNP complex between human spliceosomal cyclophilin H and a U4/U6-60K peptide 1qoi: U4/U6 SNRNP-SPECIFIC CYCLOPHILIN SNUCYP-20

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