PPP2R2C

PPP2R2C
Identifiers
Aliases	PPP2R2C, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, B55gamma
External IDs	OMIM: 605997; MGI: 2442660; GeneCards: PPP2R2C
Gene location (Human)
Chr.	Chromosome 4 (human)
End	6,563,600 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	37,112,422 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; parietal lobe; ; postcentral gyrus; ; occipital lobe; ; Brodmann area 23; ; entorhinal cortex; ; primary visual cortex; ; prefrontal cortex;
	Top expressed in
	visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; primary motor cortex; ; piriform cortex; ; prefrontal cortex; ; cingulate gyrus; ; olfactory tubercle; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein serine/threonine phosphatase activity; protein phosphatase regulator activity;
Cellular component	protein phosphatase type 2A complex; cytosol;
Biological process	mitotic cell cycle; peptidyl-serine dephosphorylation; developmental process; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5522
	269643
	ENSG00000074211
	ENSMUSG00000029120
	Q9Y2T4
	Q8BG02
NM_001206994; NM_001206995; NM_001206996; NM_020416; NM_181876;
	NM_001363388
	NM_172994; NM_001360003
NP_001193923; NP_001193924; NP_001193925; NP_065149; NP_870991;
	NP_001350317
	NP_766582; NP_001346932
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000074211 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029120 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (October 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research. 6 (5): 323–327. doi:10.1093/dnares/6.5.323. PMID 10574460.
↑ Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, et al. (July 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics. 67 (1): 83–86. doi:10.1006/geno.2000.6219. PMID 10945473.
1 2 "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform".

Zolnierowicz S (October 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology. 60 (8): 1225–1235. doi:10.1016/S0006-2952(00)00424-X. PMID 11007961.
Andersen JL, Planelles V (January 2005). "The role of Vpr in HIV-1 pathogenesis". Current HIV Research. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
Zhao RY, Elder RT (March 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–149. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (April 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–286. PMID 15817944.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (January 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2–3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886. S2CID 23293768.
Ruediger R, Brewis N, Ohst K, Walter G (November 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–443. doi:10.1006/viro.1997.8873. PMID 9400615.
Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE (March 1998). "Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits". The Journal of Comparative Neurology. 392 (4): 515–527. doi:10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3. PMID 9514514. S2CID 20496320.
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (September 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–370. doi:10.1006/viro.2001.1007. PMID 11531413.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, et al. (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–3170. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, et al. (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". The Journal of Biological Chemistry. 278 (42): 40829–40836. doi:10.1074/jbc.M308678200. PMID 12912990.
Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC (February 2004). "Identification of specific PP2A complexes involved in human cell transformation". Cancer Cell. 5 (2): 127–136. doi:10.1016/S1535-6108(04)00026-1. PMID 14998489.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000074211 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029120 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Torres_1999-5] Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (October 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research. 6 (5): 323–327. doi:10.1093/dnares/6.5.323. PMID 10574460.

[Hu_2000-6] Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, et al. (July 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics. 67 (1): 83–86. doi:10.1006/geno.2000.6219. PMID 10945473.

[entrez-7] 1 2 "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform".

PPP2R2C

Function

References

Further reading