PPP4R3B

PPP4R3B
Identifiers
Aliases	PPP4R3B, FLFL2, PP4R3B, PSY2, smk1, SMEK2, protein phosphatase 4 regulatory subunit 3B
External IDs	OMIM: 610352; MGI: 2144474; GeneCards: PPP4R3B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	55,618,880 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	29,220,797 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; buccal mucosa cell; ; jejunal mucosa; ; ventricular zone; ; Achilles tendon; ; ganglionic eminence; ; mucosa of paranasal sinus; ; mucosa of sigmoid colon; ; epithelium of colon; ; tonsil;
	Top expressed in
	saccule; ; spermatocyte; ; otic placode; ; otic vesicle; ; spermatid; ; genital tubercle; ; olfactory epithelium; ; blood; ; medullary collecting duct; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; centrosome; protein phosphatase 4 complex; cytoskeleton; nucleus; nucleoplasm; microtubule organizing center; nuclear speck;
Biological process	regulation of lipid metabolic process; protein dephosphorylation; positive regulation of gluconeogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57223
	104570
	ENSG00000275052
	ENSMUSG00000020463
	Q5MIZ7
	Q922R5
	NM_001122964; NM_001282850; NM_020463
	NM_134034
	NP_001116436; NP_001269779; NP_065196
NP_598795; NP_001350287; NP_001350288; NP_001350289; NP_001350290;
	NP_001350291
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 4 regulatory subunit 3B is a protein that in humans is encoded by the PPP4R3B gene (previously SMEK2). This protein functions as a regulatory subunit for a serine/threonine-protein phosphatase 4 complex formed out of PPP4C, PPP4R2, and PPP4R3B.

Interactions

SMEK2 has been shown to interact with PPP4C.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000275052 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020463 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012. Archived from the original (PDF) on 2021-03-02. Retrieved 2019-09-20.
↑ Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J (Jul 2008). "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication". Molecular Cell. 31 (1): 33–46. doi:10.1016/j.molcel.2008.05.016. PMC 3242369. PMID 18614045.
↑ "Entrez Gene: SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)".
↑ "Serine/threonine-protein phosphatase 4 regulatory subunit 3B". uniprot.org. UniProt consortium. Retrieved 2026-09-12.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Feb 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer K, Pisabarro MT, Buchholz F (Dec 2004). "An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division". Nature. 432 (7020): 1036–40. Bibcode:2004Natur.432.1036K. doi:10.1038/nature03159. PMID 15616564. S2CID 4372785.
Mendoza MC, Du F, Iranfar N, Tang N, Ma H, Loomis WF, Firtel RA (Sep 2005). "Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects". Molecular and Cellular Biology. 25 (17): 7839–53. doi:10.1128/MCB.25.17.7839-7853.2005. PMC 1190274. PMID 16107728.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000275052 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020463 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16085932-5] 1 2 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012. Archived from the original (PDF) on 2021-03-02. Retrieved 2019-09-20.

[pmid18614045-6] Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J (Jul 2008). "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication". Molecular Cell. 31 (1): 33–46. doi:10.1016/j.molcel.2008.05.016. PMC 3242369. PMID 18614045.

[entrez-7] "Entrez Gene: SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)".

[8] "Serine/threonine-protein phosphatase 4 regulatory subunit 3B". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid18715871-10] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

PPP4R3B

Interactions

References

Further reading