PPP6R3

PPP6R3
Identifiers
Aliases	PPP6R3, C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3, protein phosphatase 6 regulatory subunit 3
External IDs	OMIM: 610879; MGI: 1921807; GeneCards: PPP6R3
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,625,749 bp
Gene ontology
Molecular function	protein phosphatase binding; protein binding;
Cellular component	plasma membrane; nucleus; nucleoplasm; Golgi membrane; cytoplasm; cytosol;
Biological process	regulation of phosphoprotein phosphatase activity; COPII vesicle coating;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55291
	52036
	ENSG00000110075
	ENSMUSG00000024908
	Q5H9R7
	Q922D4
NM_001164160; NM_001164161; NM_001164162; NM_001164163; NM_001164164;
	NM_018312
	NM_001164159; NM_028999; NM_029456; NM_001360429; NM_001360430
NP_001157632; NP_001157633; NP_001157634; NP_001157635; NP_001157636;
	NP_060782; NP_001339276; NP_001339277; NP_001339279; NP_001339280; NP_001339281; NP_001339282; NP_001339283; NP_001339284; NP_001339285; NP_001339286; NP_001339287; NP_001339288; NP_001339289; NP_001339290; NP_001339291; NP_001339292; NP_001339293; NP_001339294; NP_001339295; NP_001339297; NP_001339298; NP_001339299; NP_001339300; NP_001339301; NP_001339302; NP_001339303; NP_001339304; NP_001339305; NP_001339306; NP_001339307; NP_001339308; NP_001339309
	NP_001157631; NP_083275; NP_083732; NP_001347358; NP_001347359
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 6 regulatory subunit 3 is a protein that in humans is encoded by the gene PPP6R3 (also termed C11orf23, PP6R3, SAP190, SAPL, SAPLa, and SAPS3). PPP6R3 is expressed in all tissues tested in humans. It encodes protein phosphatase 6 regulatory subunit 3 (PP6RS3). PP6RS3 is the function-regulating subunit of protein phosphatase 6 (PPP6C). PPP6C is a component of a signaling pathway that regulates various cell functions including cell division, the repair of damaged DNA, inflammatory responses, messenger mRNA splicing, and the stability of chromosomes.

Two cases of nodular fasciitis have malignant tumors in which the neoplastic cells expressed a PPP6R3 gene merged to the USP6 (i.e. ubiquitin carboxyl-terminal hydrolase 6) gene to form an USP-PPP6R3 fusion gene. In both of these cases, the USP-PPP6R3 fusion genes was considered to contribute to these tumors malignancy.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024908 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "PPP6R3 – Gene – NCBI".
↑ "USP6 ubiquitin specific peptidase 6 [Homo sapiens (Human)] - Gene – NCBI".
1 2 Teramura Y, Yamazaki Y, Tanaka M, Sugiura Y, Takazawa Y, Takeuchi K, Nakayama T, Kaneko T, Musha Y, Funauchi Y, Ae K, Matsumoto S, Nakamura T (December 2019). "Case of mesenchymal tumor with the PPP6R3-USP6 fusion, possible nodular fasciitis with malignant transformation". Pathology International. 69 (12): 706–709. doi:10.1111/pin.12851. PMID 31538390. S2CID 202701385.
↑ "PPP6R3 – Serine/Threonine-protein phosphatase 6 regulatory subunit 3 – Homo sapiens (Human) – PPP6R3 gene & protein".
↑ Kitamura N, Fujiwara N, Hayakawa K, Ohama T, Sato K (July 2021). "Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells". Journal of Biochemistry. 170 (1): 131–138. doi:10.1093/jb/mvab028. PMID 34314486.
1 2 Guo R, Wang X, Chou MM, Asmann Y, Wenger DE, Al-Ibraheemi A, Molavi DW, Aboulafia A, Jin L, Fritchie K, Oliveira JL, Jenkins RB, Westendorf JJ, Dong J, Oliveira AM (August 2016). "PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis". Genes, Chromosomes & Cancer. 55 (8): 640–9. doi:10.1002/gcc.22366. PMID 27113271. S2CID 4378693.
↑ Nakayama S, Nishio J, Aoki M, Koga K, Nabeshima K, Yamamoto T (2021). "Ubiquitin-specific Peptidase 6 (USP6)-associated Fibroblastic/Myofibroblastic Tumors: Evolving Concepts". Cancer Genomics & Proteomics. 18 (2): 93–101. doi:10.21873/cgp.20244. PMC 7943209. PMID 33608306.

External links

Atlas of Genetics

PPPR63

GeneCard for PPP6R3

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024908 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "PPP6R3 – Gene – NCBI".

[5] "USP6 ubiquitin specific peptidase 6 [Homo sapiens (Human)] - Gene – NCBI".

[pmid31538390-6] 1 2 Teramura Y, Yamazaki Y, Tanaka M, Sugiura Y, Takazawa Y, Takeuchi K, Nakayama T, Kaneko T, Musha Y, Funauchi Y, Ae K, Matsumoto S, Nakamura T (December 2019). "Case of mesenchymal tumor with the PPP6R3-USP6 fusion, possible nodular fasciitis with malignant transformation". Pathology International. 69 (12): 706–709. doi:10.1111/pin.12851. PMID 31538390. S2CID 202701385.

[7] "PPP6R3 – Serine/Threonine-protein phosphatase 6 regulatory subunit 3 – Homo sapiens (Human) – PPP6R3 gene & protein".

[pmid34314486-8] Kitamura N, Fujiwara N, Hayakawa K, Ohama T, Sato K (July 2021). "Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells". Journal of Biochemistry. 170 (1): 131–138. doi:10.1093/jb/mvab028. PMID 34314486.

[pmid27113271-9] 1 2 Guo R, Wang X, Chou MM, Asmann Y, Wenger DE, Al-Ibraheemi A, Molavi DW, Aboulafia A, Jin L, Fritchie K, Oliveira JL, Jenkins RB, Westendorf JJ, Dong J, Oliveira AM (August 2016). "PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis". Genes, Chromosomes & Cancer. 55 (8): 640–9. doi:10.1002/gcc.22366. PMID 27113271. S2CID 4378693.

[pmid33608306-10] Nakayama S, Nishio J, Aoki M, Koga K, Nabeshima K, Yamamoto T (2021). "Ubiquitin-specific Peptidase 6 (USP6)-associated Fibroblastic/Myofibroblastic Tumors: Evolving Concepts". Cancer Genomics & Proteomics. 18 (2): 93–101. doi:10.21873/cgp.20244. PMC 7943209. PMID 33608306.