Peroxiredoxin 1

PRDX1
Identifiers
AliasesPRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2, Peroxiredoxin 1
External IDsOMIM: 176763; MGI: 99523; GeneCards: PRDX1
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
1.11.1.24↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

5052

18477

Ensembl

ENSG00000117450

ENSMUSG00000028691

UniProt

Q06830

P35700

RefSeq (mRNA)

NM_181697
NM_001202431
NM_002574
NM_181696

NM_011034

RefSeq (protein)

NP_001189360
NP_002565
NP_859047
NP_859048

NP_035164

Location (UCSC)Chr 1: 45.51 – 45.54 MbChr 4: 116.54 – 116.56 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.

Function

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.

Interactions

Peroxiredoxin 1 has been shown to interact with PRDX4. A chemoproteomic approach has revealed that peroxiredoxin 1 is the main target of theonellasterone.

Clinical significance

As enzymes that combat oxidative stress, peroxiredoxins play an important role in health and disease. Peroxiredoxin 1 and peroxiredoxin 2 have been shown to be released by some cells when stimulated by LPS or TNF-alpha. The released peroxiredoxin can then act to produce inflammatory cytokines. The levels of peroxiredoxin 1 are elevated in pancreatic cancer and it can potentially act as a marker for the diagnosis and prognosis of this disease. In some types of cancer, peroxiredoxin 1 has been determined to act as a tumor suppressor and other studies show that peroxiredoxin 1 is overexpressed in certain human cancers. A recent study has found that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma. The expression patterns of peroxiredoxin 1 along with peroxiredoxin 4 are involved in human lung cancer malignancy. It has also been shown that peroxiredoxin 1 may be an important player in the pathogenesis of acute respiratory distress syndrome because of its role in promoting inflammation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117450 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028691 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Prospéri MT, Ferbus D, Karczinski I, Goubin G (May 1993). "A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins". The Journal of Biological Chemistry. 268 (15): 11050–11056. doi:10.1016/S0021-9258(18)82090-7. PMID 8496166.
  6. 1 2 "Entrez Gene: PRDX1 peroxiredoxin 1".
  7. ↑ Wu C, Dai H, Yan L, Liu T, Cui C, Chen T, et al. (July 2017). "Sulfonation of the resolving cysteine in human peroxiredoxin 1: A comprehensive analysis by mass spectrometry". Free Radical Biology & Medicine. 108: 785–792. doi:10.1016/j.freeradbiomed.2017.04.341. PMC 5564515. PMID 28450148.
  8. ↑ Jin DY, Chae HZ, Rhee SG, Jeang KT (December 1997). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". The Journal of Biological Chemistry. 272 (49): 30952–30961. doi:10.1074/jbc.272.49.30952. PMID 9388242.
  9. ↑ Margarucci L, Monti MC, Tosco A, Esposito R, Zampella A, Sepe V, et al. (January 2015). "Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions". Chemical Communications. 51 (9): 1591–1593. doi:10.1039/c4cc09205h. PMID 25503482. S2CID 11393982.
  10. ↑ El Eter E, Al-Masri AA (May 2015). "Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus". Brazilian Journal of Medical and Biological Research. 48 (5): 465–469. doi:10.1590/1414-431X20144142. PMC 4445671. PMID 25742636.
  11. 1 2 Mullen L, Hanschmann EM, Lillig CH, Herzenberg LA, Ghezzi P (2015). "Cysteine Oxidation Targets Peroxiredoxins 1 and 2 for Exosomal Release through a Novel Mechanism of Redox-Dependent Secretion". Molecular Medicine. 21 (1): 98–108. doi:10.2119/molmed.2015.00033. PMC 4461588. PMID 25715249.
  12. ↑ Cai CY, Zhai LL, Wu Y, Tang ZG (February 2015). "Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer". European Journal of Surgical Oncology. 41 (2): 228–235. doi:10.1016/j.ejso.2014.11.037. PMID 25434328.
  13. 1 2 Gong F, Hou G, Liu H, Zhang M (February 2015). "Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma". Medical Oncology. 32 (2): 455. doi:10.1007/s12032-014-0455-0. PMID 25579166. S2CID 5123492.
  14. ↑ Jiang H, Wu L, Mishra M, Chawsheen HA, Wei Q (2014). "Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy". American Journal of Cancer Research. 4 (5): 445–460. PMC 4163610. PMID 25232487.
  15. ↑ Liu D, Mao P, Huang Y, Liu Y, Liu X, Pang X, et al. (2014). "Proteomic analysis of lung tissue in a rat acute lung injury model: identification of PRDX1 as a promoter of inflammation". Mediators of Inflammation. 2014: 1–14. doi:10.1155/2014/469358. PMC 4082880. PMID 25024510.

Further reading