PRKAR1B

PRKAR1B
Identifiers
Aliases	PRKAR1B, PRKAR1, protein kinase cAMP-dependent type I regulatory subunit beta, MASNS
External IDs	OMIM: 176911; MGI: 97759; GeneCards: PRKAR1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DIN, 4F9K
Gene location (Human)
Chr.	Chromosome 7 (human)
End	727,650 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	139,135,756 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; frontal pole; ; Brodmann area 9; ; amygdala; ; nucleus accumbens; ; right hemisphere of cerebellum; ; hypothalamus;
	Top expressed in
	substantia nigra; ; motor neuron; ; dorsal tegmental nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; prefrontal cortex; ; subiculum; ; pontine nuclei; ; anterior amygdaloid area; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein kinase A catalytic subunit binding; cAMP binding; cAMP-dependent protein kinase regulator activity; cAMP-dependent protein kinase inhibitor activity; protein binding; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytosol; membrane; plasma membrane; ciliary base; cAMP-dependent protein kinase complex; synapse; Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse;
Biological process	regulation of protein phosphorylation; activation of protein kinase A activity; cellular response to glucagon stimulus; blood coagulation; negative regulation of cAMP-dependent protein kinase activity; protein phosphorylation; renal water homeostasis; learning or memory; modulation of chemical synaptic transmission; regulation of synaptic vesicle cycle; cGMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5575
	19085
	ENSG00000188191
	ENSMUSG00000025855
	P31321
	P12849
NM_001164758; NM_001164759; NM_001164760; NM_001164761; NM_001164762;
	NM_002735
NM_001253890; NM_008923; NM_001359097; NM_001359098; NM_001359099;
	NM_001359100; NM_001359101
NP_001158230; NP_001158231; NP_001158232; NP_001158233; NP_001158234;
	NP_002726
NP_001240819; NP_032949; NP_001346026; NP_001346027; NP_001346028;
	NP_001346029; NP_001346030
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.

Clinical significance

Mutations in PRKAR1B cause neurodegenerative disorder.

Interactions

PRKAR1B has been shown to interact with AKAP1 and PRKAR1A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188191 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025855 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
↑ Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018.
↑ "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".
↑ Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. hdl:20.500.11755/abb6522f-5c5a-4833-a89e-342ac6dd3193. PMID 24722252.
1 2 Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
↑ Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.

External links

Overview of all the structural information available in the PDB for UniProt: P31321 (Human cAMP-dependent protein kinase type I-beta regulatory subunit) at the PDBe-KB.

This protein-related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188191 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1358799-5] Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Dec 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.

[pmid3479018-6] Scambler P, Oyen O, Wainwright B, Farrall M, Law HY, Estivill X, Sandberg M, Williamson R, Jahnsen T (Dec 1987). "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet. 41 (5): 925–32. PMC 1684338. PMID 3479018.

[entrez-7] "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta".

[8] Wong TH, Chiu WZ, Breedveld GJ, Li KW, Verkerk AJ, Hondius D, Hukema RK, Seelaar H, Frick P, Severijnen LA, Lammers GJ, Lebbink JH, van Duinen SG, Kamphorst W, Rozemuller AJ, Bakker EB, Neumann M, Willemsen R, Bonifati V, Smit AB, van Swieten J (2014). "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain. 137 (Pt 5): 1361–73. doi:10.1093/brain/awu067. hdl:20.500.11755/abb6522f-5c5a-4833-a89e-342ac6dd3193. PMID 24722252.

[pmid12634056-9] 1 2 Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.

[pmid8407966-10] Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (Oct 1993). "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.

PRKAR1B

Clinical significance

Interactions

References

Further reading

External links