PRP4K Protein-coding gene in the species Homo sapiens
PRP4K Identifiers Aliases PRP4K External IDs OMIM : 602338 ; MGI : 109584 ; GeneCards : PRP4K Gene location (Mouse ) Chr. Chromosome 13 (mouse) Band 13| 13 A3.3 Start 34,875,302 bp End 34,906,064 bp
Wikidata
Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRP4K gene . The gene was previously known as PRPF4B.
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000112739 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021413 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (1): 31– 9. doi :10.1093/dnares/5.1.31 PMID 9628581 . ↑ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1" . J Biol Chem . 276 (34): 32247– 56. doi :10.1074/jbc.M103790200 PMID 11418604 . 1 2 "Entrez Gene: PRP4K PRP4 pre-mRNA processing factor 4 homolog B (yeast)" .↑ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes" . Mol. Cell. Biol . 22 (14). United States: 5141– 56. doi :10.1128/MCB.22.14.5141-5156.2002 . hdl :11858/00-001M-0000-0029-BC76-A . ISSN 0270-7306 . PMC 139773 PMID 12077342 .
Further reading
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ . 4 (10): 821– 30. PMID 8274451 . Gross T, Lützelberger M, Weigmann H, et al. (1997). "Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue" . Nucleic Acids Res . 25 (5): 1028– 35. doi :10.1093/nar/25.5.1028 . PMC 146536 PMID 9102632 . Huang Y, Deng T, Winston BW (2000). "Characterization of hPRP4 kinase activation: potential role in signaling". Biochem. Biophys. Res. Commun . 271 (2): 456– 63. doi :10.1006/bbrc.2000.2651 . PMID 10799319 . Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426– 39. doi :10.1017/S1355838202021088 . PMC 1370266 PMID 11991638 . Dellaire G, Makarov EM, Cowger JJ, et al. (2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes" . Mol. Cell. Biol . 22 (14): 5141– 56. doi :10.1128/MCB.22.14.5141-5156.2002 . PMC 139773 PMID 12077342 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707– 16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130– 5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Bennett EM, Lever AM, Allen JF (2004). "Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2" . J. Virol . 78 (20): 11303– 12. doi :10.1128/JVI.78.20.11303-11312.2004 . PMC 521795 PMID 15452250 . Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol . 23 (1): 94– 101. doi :10.1038/nbt1046 . PMID 15592455 . S2CID 7200157 . Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules" . Mol. Cell. Proteomics . 4 (9): 1240– 50. doi :10.1074/mcp.M500089-MCP200 PMID 15951569 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957– 68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391– 6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285– 92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription" . J. Immunol . 178 (11): 7081– 7. doi :10.4049/jimmunol.178.11.7081 . PMC 2674583 PMID 17513757 .
