PRXL2B

PRXL2B
Identifiers
Aliases	PRXL2B, C1orf93, family with sequence similarity 213 member B, peroxiredoxin like 2B, FAM213B
External IDs	MGI: 1913719; GeneCards: PRXL2B
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,591,469 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	154,983,592 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; anterior cingulate cortex; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; superior frontal gyrus; ; duodenum; ; Brodmann area 9; ; hypothalamus; ; temporal lobe;
	Top expressed in
	olfactory epithelium; ; triceps brachii muscle; ; facial motor nucleus; ; interventricular septum; ; sternocleidomastoid muscle; ; temporal muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; digastric muscle; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; oxidoreductase activity; prostaglandin-F synthase activity; antioxidant activity;
Cellular component	cytoplasm; myelin sheath; cytosol; extracellular exosome; endoplasmic reticulum;
Biological process	prostaglandin metabolic process; prostaglandin biosynthetic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolism; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	127281
	66469
	ENSG00000275125; ENSG00000157870
	ENSMUSG00000029059
	Q8TBF2
	Q9DB60
NM_001195736; NM_001195737; NM_001195738; NM_001195740; NM_001195741;
	NM_152371
	NM_025582
NP_001182665; NP_001182666; NP_001182667; NP_001182669; NP_001182670;
	NP_689584
	NP_079858
	Wikidata
View/Edit Human	View/Edit Mouse

PRXL2B is a gene found in humans that encodes the enzyme prostamide/prostaglandin F synthase (EC 1.11.1.20). Like prostaglandin F synthase (encoded by the gene AKR1C3), PRXL2B produces the labor inducing hormone prostaglandin F2alpha, but differs from AKR1C3 in the substrates it uses to produce it. PRXL2B catalyzes the following reaction: