PURB

PURB
Identifiers
Aliases	PURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDs	OMIM: 608887; MGI: 1338779; GeneCards: PURB
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,885,530 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,425,917 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; cerebellar vermis; ; pancreatic epithelial cell; ; gingival epithelium; ; pancreatic ductal cell; ; visceral pleura; ; Brodmann area 23; ; tibialis anterior muscle; ; epithelium of nasopharynx; ; myocardium of left ventricle;
	Top expressed in
	lateral septal nucleus; ; anterior amygdaloid area; ; Region I of hippocampus proper; ; primary motor cortex; ; piriform cortex; ; olfactory tubercle; ; cingulate gyrus; ; superior colliculus; ; lateral geniculate nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA binding; double-stranded DNA binding; SMAD binding; single-stranded DNA binding; transcription factor binding; mRNA binding; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; purine-rich negative regulatory element binding; sequence-specific DNA binding;
Cellular component	DNA replication factor A complex; nucleus;
Biological process	regulation of myeloid cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; cell population proliferation; cell differentiation; transcription, DNA-templated; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5814
	19291
	ENSG00000146676
	ENSMUSG00000094483
	Q96QR8
	O35295
	NM_033224
	NM_011221
	NP_150093
	NP_035351
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.

Function

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription.

Clinical significance

Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146676 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000094483 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bergemann AD, Ma ZW, Johnson EM (December 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Molecular and Cellular Biology. 12 (12): 5673–5682. doi:10.1128/mcb.12.12.5673. PMC 360507. PMID 1448097.
1 2 "Entrez Gene: PURB purine-rich element binding protein B".

Kelm RJ, Cogan JG, Elder PK, Strauch AR, Getz MJ (May 1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". The Journal of Biological Chemistry. 274 (20): 14238–14245. doi:10.1074/jbc.274.20.14238. PMID 10318844.
Lezon-Geyda K, Najfeld V, Johnson EM (2001). "Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia". Leukemia. 15 (6): 954–962. doi:10.1038/sj.leu.2402108. PMID 11417483. S2CID 7186291.
Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP (November 2003). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". The Journal of Biological Chemistry. 278 (45): 44935–44948. doi:10.1074/jbc.M307696200. PMID 12933792.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146676 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000094483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Bergemann_1992-5] Bergemann AD, Ma ZW, Johnson EM (December 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Molecular and Cellular Biology. 12 (12): 5673–5682. doi:10.1128/mcb.12.12.5673. PMC 360507. PMID 1448097.

[entrez-6] 1 2 "Entrez Gene: PURB purine-rich element binding protein B".

PURB

Function

Clinical significance

References

Further reading