PYGO2

PYGO2

Identifiers

PYGO2, 1190004M21Rik, pygopus family PHD finger 2

External IDs

OMIM: 606903; MGI: 1916161; GeneCards: PYGO2

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2XB1, 4UP0, 4UP5

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q21.3	Start	154,957,026 bp
Band	1q21.3	End	154,963,853 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3\|3 F1	Start	89,337,521 bp
Band	3\|3 F1	End	89,342,435 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

skin of arm

cardiac muscle tissue of right atrium

myocardium of left ventricle

nasal epithelium

cardia

right adrenal gland

anterior pituitary

right adrenal cortex

granulocyte

oocyte

Top expressed in

papillary dermis

yolk sac

granulocyte

dermal papilla

cumulus cell

gastrula

ventricular zone

lens

epiblast

lip

More reference expression data

n/a

Gene ontology
Molecular function	histone binding metal ion binding protein binding chromatin binding histone acetyltransferase regulator activity
Cellular component	nucleoplasm nucleus beta-catenin-TCF complex
Biological process	roof of mouth development regulation of histone H3-K4 methylation in utero embryonic development regulation of mammary gland epithelial cell proliferation positive regulation of chromatin binding mammary gland development brain development lens development in camera-type eye developmental growth regulation of histone acetylation spermatid development canonical Wnt signaling pathway beta-catenin-TCF complex assembly kidney development spermatid nucleus differentiation post-embryonic development Wnt signaling pathway
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


90780


68911


ENSG00000163348


ENSMUSG00000047824


Q9BRQ0


n/a

RefSeq (mRNA)


NM_138300


NM_001293763 NM_001293766 NM_001293767 NM_001293768 NM_026869

RefSeq (protein)


NP_612157


n/a

Location (UCSC)

Chr 1: 154.96 – 154.96 Mb

Chr 3: 89.34 – 89.34 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163348 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047824 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol. 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739. S2CID 23942463.
↑ "Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

Further reading

Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex" (PDF). Cell. 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446. S2CID 16720801. Archived from the original (PDF) on 2021-09-26. Retrieved 2021-01-31.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447. S2CID 6880212.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037. S2CID 3260972.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272. S2CID 17642255.
Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. doi:10.3892/ijo.30.2.357 (inactive 12 July 2025). PMID 17203217.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)

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