Panachaiki Gymnastiki Enosi (Greek: Παναχαϊκή Γυμναστική Ένωση, lit. 'Panachaean Gymnastic Union') is a Greek multisports club based in Patras, Greece.
The history of Panachaiki G.E. began on 14 June 1891, when Panachaikos Gymnastikos Syllogos (Greek: Παναχαϊκός Γυμναστικός Σύλλογος, lit. 'Panachaean Gymnastic Club') was founded. In 1894, a rival sports club, Gymnastiki Etaireia Patron (Greek: Γυμναστική Εταιρεία Πατρών, lit. 'Patras Gymnastic Company'), was founded in Patras by former Panachaikos' members. It was only in 1923 that the two clubs agreed to merge, forming Panachaiki Gymnastiki Enosi.
Throughout a history of over 120 years, Panachaiki's athletes have won several Olympic medals. Emblematic figures in Panachaiki's history are weightlifter Dimitrios Tofalos and Kostas Davourlis, leader of the great football team that impressed Greece in the 1970s and took part in the 1973–74 UEFA Cup, being the first Greek countryside football club (outside Athens and Thessaloniki) to achieve that distinction.

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