Plasmepsin II

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Plasmepsin II
Plasmepsin II
Identifiers
EC no.	3.4.23.39
CAS no.	159447-18-4
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

Plasmepsin II (EC 3.4.23.39, aspartic hemoglobinase II, PFAPD) is an enzyme. This enzyme catalyses the following chemical reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO₂)-Ser-Phe-Pro-Thr

This enzyme is present in malaria organism, Plasmodium.

References

↑ Dame JB, Reddy GR, Yowell CA, Dunn BM, Kay J, Berry C (April 1994). "Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Molecular and Biochemical Parasitology. 64 (2): 177–90. doi:10.1016/0166-6851(94)90024-8. PMID 7935597.
↑ Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE (April 1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation. 93 (4): 1602–8. doi:10.1172/JCI117140. PMC 294190. PMID 8163662.
↑ Hill J, Tyas L, Phylip LH, Kay J, Dunn BM, Berry C (September 1994). "High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Letters. 352 (2): 155–8. Bibcode:1994FEBSL.352..155H. doi:10.1016/0014-5793(94)00940-6. PMID 7925966.

External links

Plasmepsin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Dame JB, Reddy GR, Yowell CA, Dunn BM, Kay J, Berry C (April 1994). "Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Molecular and Biochemical Parasitology. 64 (2): 177–90. doi:10.1016/0166-6851(94)90024-8. PMID 7935597.

[2] Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE (April 1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation. 93 (4): 1602–8. doi:10.1172/JCI117140. PMC 294190. PMID 8163662.

[3] Hill J, Tyas L, Phylip LH, Kay J, Dunn BM, Berry C (September 1994). "High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Letters. 352 (2): 155–8. Bibcode:1994FEBSL.352..155H. doi:10.1016/0014-5793(94)00940-6. PMID 7925966.

v t e Proteases: aspartate proteases (EC 3.4.23)
Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2
Pathogenic	Plasmepsin HIV-1 protease
Plant	Nepenthesin
Cathepsin	D E

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)