Plectasin

Plectasin is an antibiotic protein from the mushroom Pseudoplectania nigrella. It was initially discovered in 2005 and commercialised by Novozymes. Plectasin belongs to the antimicrobial peptide class called fungal defensins, which is also present in invertebrates such as flies and mussels.[citation needed]

Clinical trials

Pre-clinical tests in mice have shown promising results in that multiresistant bacteria have problems mutating resistance against plectasin, which acts by directly binding the bacterial cell-wall precursor Lipid II in a supramolecular complex.

At the end of 2008, Novozymes signed a global licensing agreement with Sanofi-Aventis for the further development and marketing of NZ2114, a derivative of plectasin, as a treatment for gram-positive bacterial infections, e.g. Streptococcus and Staphylococcus which are resistant to all existing antibiotics.

References

  1. ↑ Mygind, Per H.; Fischer, Rikke L.; Schnorr, Kirk M.; Hansen, Mogens T.; Sönksen, Carsten P.; Ludvigsen, Svend; Raventós, Dorotea; Buskov, Steen; Christensen, Bjarke; De Maria, Leonardo; Taboureau, Olivier (2005). "Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus". Nature. 437 (7061): 975–980. Bibcode:2005Natur.437..975M. doi:10.1038/nature04051. ISSN 1476-4687. PMID 16222292. S2CID 4423851.
  2. 1 2 "Novozymes reveals knowledge on new antibiotic against resistant bacteria". Novozymes. 2010-05-28. Retrieved 2010-05-28.
  3. ↑ "Plectasin NZ2114 - Novel Microbial Agent". Drug Development Technology. Retrieved 2010-05-28.
  4. ↑ Kristensen, HH; et al. (2010). "Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II". Science. 328 (5982): 1168–1172. Bibcode:2010Sci...328.1168S. doi:10.1126/science.1185723. hdl:1874/202594. PMID 20508130. S2CID 206524928.
  5. ↑ Jekhmane, S., Derks. M. (2024). "Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism". Nature Microbiology. 9 (7): 1778–1791. doi:10.1038/s41564-024-01696-9. PMC 11222147. PMID 38783023.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ↑ Kristensen, HH; et al. (2009). "In Vivo Pharmacodynamic Characterization of a Novel Plectasin Antibiotic, NZ2114, in a Murine Infection Model". Antimicrob. Agents Chemother. 53 (7): 3003–3009. doi:10.1128/AAC.01584-08. PMC 2704636. PMID 19414576.