Propazepine

Propazepine
Names
	Preferred IUPAC name 3-(6,11-Dihydro-5H-dibenzo[b,e]azepin-5-yl)-N,N-dimethylpropan-1-amine
	Other names Prazepine, Proazepine
Identifiers
CAS Number	73-07-4;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2105257;
ChemSpider	264414;
PubChem CID	299322;
UNII	72O4809PU1;
CompTox Dashboard (EPA)	DTXSID00223272 ;
	InChI InChI=1S/C19H24N2/c1-20(2)12-7-13-21-15-18-10-4-3-8-16(18)14-17-9-5-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 Key: UKCVXGBHVGMFCN-UHFFFAOYSA-N;
	SMILES CN(C)CCCN1CC2=CC=CC=C2CC3=CC=CC=C31;
Properties
Chemical formula	C19H24N2
Molar mass	280.415 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Propazepine is a tricyclic antidepressant (TCA). Propazepine is sometimes confused with imipramine, which has the central ring nitrogen in a different location. Prazepine is the International nonproprietary name of this compound. Prazepine is also reported to be one of the many synonyms of imipramine. Propazepine can be synthesized chemically. Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests;^{[citation needed]} therefore, there is little information about it.

References

1 2 Benešová, O.; Bohdanecký, Z.; Votava, Z. (1962). "Electrophysiological comparison of the action of imipramine and propazepine". Psychopharmacologia. 3 (6): 423–431. doi:10.1007/BF00411159. PMID 13967414. S2CID 1109255.
↑ "Propazepine – C19H24N2". Pubchem.
↑ "Imipramine – C19H24N2". ChemSpider.
↑ Werner, L. H.; Ricca, S.; Mohacsi, E.; Rossi, A.; Arya, V. P. (1965). "Derivatives of Morphanthridine". Journal of Medicinal Chemistry. 8: 74–80. doi:10.1021/jm00325a016. PMID 14287270.
↑ Jílek, J. O.; Pomykáček, J.; Svátek, E.; Seidlová, V.; Rajšner, M.; Pelz, K.; Hoch, B.; Protiva, M. (1965). "Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins" [Neurotropic and psychotropic substances II. Morphanthridin and derivatives. New Synthesis of propazepins]. Collection of Czechoslovak Chemical Communications (in Czech). 30 (2): 445–462. doi:10.1135/cccc19650445.

Vojtechovsky, M; Safratova, V; Soukupova, B (1970). "The influence of propazepine on learning and memory in healthy volunteers and in patients with slight chronic brain syndrome". Activitas Nervosa Superior (in Czech). 12 (3): 251–2. ISSN 0001-7604. PMID 5457443.
Rysánek, K; Vítek, V; Svehla, C (1965). "Serotonin level in human and animal thrombocytes after imipramine and propazepine administration". Activitas Nervosa Superior (in Czech). 7 (3): 261–2. ISSN 0001-7604. PMID 5882104.
Souskova, M; Votava, Z; Roth, Z (1964). "Effect of Iproniazid, Propazepine, Reserpine and Their Combinations on the Orientation Reaction and Conditioned Defense Reaction in Rats". Activitas Nervosa Superior (in Czech). 6: 258–67. ISSN 0001-7604. PMID 14179381.
Vinarova, M; Nahunek, K; Vencovsky, E; Bast Ecky, J; Hadlik, J (1962). "Blind comparison of clinical effects of Imipramine and Propazepine". Activitas Nervosa Superior (in Czech). 4: 227–8. ISSN 0001-7604. PMID 13926058.
Souskova, M; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by a conditioned reflex method in rats". Activitas Nervosa Superior (in Czech). 4: 218–9. ISSN 0001-7604. PMID 13915453.
Benesova, O; Bohdanecky, Z; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by electrophysiological methods on animals with implanted electrodes". Activitas Nervosa Superior (in Czech). 4: 215–6. ISSN 0001-7604. PMID 13867184.
Metysova, J; Votava, Z (1961). "Comparison of pharmacological properties of propazepine and imipramine". Activitas Nervosa Superior (in Czech). 3: 227. ISSN 0001-7604. PMID 14473038.

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[BF00411159-1] 1 2 Benešová, O.; Bohdanecký, Z.; Votava, Z. (1962). "Electrophysiological comparison of the action of imipramine and propazepine". Psychopharmacologia. 3 (6): 423–431. doi:10.1007/BF00411159. PMID 13967414. S2CID 1109255.

[2] "Propazepine – C19H24N2". Pubchem.

[3] "Imipramine – C19H24N2". ChemSpider.

[4] Werner, L. H.; Ricca, S.; Mohacsi, E.; Rossi, A.; Arya, V. P. (1965). "Derivatives of Morphanthridine". Journal of Medicinal Chemistry. 8: 74–80. doi:10.1021/jm00325a016. PMID 14287270.

[5] Jílek, J. O.; Pomykáček, J.; Svátek, E.; Seidlová, V.; Rajšner, M.; Pelz, K.; Hoch, B.; Protiva, M. (1965). "Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins" [Neurotropic and psychotropic substances II. Morphanthridin and derivatives. New Synthesis of propazepins]. Collection of Czechoslovak Chemical Communications (in Czech). 30 (2): 445–462. doi:10.1135/cccc19650445.

Propazepine

References

Further reading