Proctosedyl

Proctosedyl is the brand name for a family of two products with identical active ingredients designed to treat a variety of proctological disorders. One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group. Manufacture and distribution is provided by Sanofi Aventis subsidiaries Hoechst and Hoechst Marion Roussel in other territories worldwide.

Application

Both the yellowish-white, translucent, greasy ointment and the smooth, off-white suppositories are formulated for the relief of chronic pruritus ani (otherwise known anal itching or anusitis) and the treatment of pain, irritation, discharge and itching associated with haemorrhoids (otherwise known as piles). However both products are also used to provide pain relief in the treatment of anal fissure, for patients undergoing haemorrhoidectomy, (pre and post-operative), in the relief of post-partum (otherwise known as post-natal) haemorrhoidal conditions, and in the treatment of non-infective proctitis.

Active ingredients

Both preparations contain:

Cinchocaine hydrochloride at a concentration of 5 mg/g to provide anaesthesia, analgesia and to act as a spasmolytic.
Hydrocortisone at a concentration of 5 mg/g. to provide antipruritic and anti-inflammatory relief

Preparations in some territories may also contain:

Framycetin sulfate at a concentration of 10 mg/g as an antibacterial agent.
Aesculin at a concentration of 10 mg/g for its retardant effect on Escherichia coli (otherwise known as E. Coli).

References

1 2 3 4 5 6 "Patient Information Leaflets Online: Proctosedyl Ointment: PL 04425/0207". Archived from the original on 2012-02-20. Retrieved 2009-01-21.
1 2 3 4 5 6 "Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208". Archived from the original on 2012-02-20. Retrieved 2009-01-21.
↑ "Sanofi Aventis: Hoechst Home Page". Archived from the original on 2009-12-19. Retrieved 2009-01-22.
1 2 3 "The South African Medical Formulary: C05A Antihaemorrhoidals for topical use". Retrieved 2009-01-22.{{cite web}}: CS1 maint: deprecated archival service (link)
1 2 "NetDoctor: Proctosedyl ointment/suppositories". Retrieved 2009-01-21.
↑ Maan MS, Mishra R, Thomas S, Hadke NS (2004). "Randomized, double-blind trial comparing topical nitroglycerine with xylocaine and Proctosedyl in idiopathic chronic anal fissure". Indian Journal of Gastroenterology. 23 (3): 91–3. PMID 15250565.
↑ "A general practitioner study to evaluate the efficacy of 'Proctosedyl' ointment in the treatment of acute fissure-in-ano". The British Journal of Clinical Practice. 24 (7): 289–91. July 1970. PMID 4919315.
1 2 3 4 5 6 "Medsafe: Information for Health Professionals: Proctosedyl". Archived from the original on October 22, 2008. Retrieved 2009-01-21.
↑ Damianov L, Katsarova M (1993). "[Our experience in using the preparation Proctosedyl from the Roussel firm in pregnant women with hemorrhoids]". Akusherstvo I Ginekologii͡a (in Bulgarian). 32 (3): 71. PMID 8037333.
↑ Larsen PO (September 1992). "[The Danish fund for basic research--a new cigar-box]". Ugeskrift for Laeger (in Danish). 154 (39): 2657. PMID 1413190.
↑ Duncan SH, Leitch EC, Stanley KN, et al. (May 2004). "Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves". The British Journal of Nutrition. 91 (5): 749–55. doi:10.1079/BJN20041101. PMID 15137927.

External links

[Xpil1-1] 1 2 3 4 5 6 "Patient Information Leaflets Online: Proctosedyl Ointment: PL 04425/0207". Archived from the original on 2012-02-20. Retrieved 2009-01-21.

[Xpil2-2] 1 2 3 4 5 6 "Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208". Archived from the original on 2012-02-20. Retrieved 2009-01-21.

[Hoechst1-3] "Sanofi Aventis: Hoechst Home Page". Archived from the original on 2009-12-19. Retrieved 2009-01-22.

[SAMF1-4] 1 2 3 "The South African Medical Formulary: C05A Antihaemorrhoidals for topical use". Retrieved 2009-01-22.{{cite web}}: CS1 maint: deprecated archival service (link)

[NetDoc1-5] 1 2 "NetDoctor: Proctosedyl ointment/suppositories". Retrieved 2009-01-21.

[PubMed1-6] Maan MS, Mishra R, Thomas S, Hadke NS (2004). "Randomized, double-blind trial comparing topical nitroglycerine with xylocaine and Proctosedyl in idiopathic chronic anal fissure". Indian Journal of Gastroenterology. 23 (3): 91–3. PMID 15250565.

[PubMed2-7] "A general practitioner study to evaluate the efficacy of 'Proctosedyl' ointment in the treatment of acute fissure-in-ano". The British Journal of Clinical Practice. 24 (7): 289–91. July 1970. PMID 4919315.

[Medsafe1-8] 1 2 3 4 5 6 "Medsafe: Information for Health Professionals: Proctosedyl". Archived from the original on October 22, 2008. Retrieved 2009-01-21.

[PubMed3-9] Damianov L, Katsarova M (1993). "[Our experience in using the preparation Proctosedyl from the Roussel firm in pregnant women with hemorrhoids]". Akusherstvo I Ginekologii͡a (in Bulgarian). 32 (3): 71. PMID 8037333.

[PubMed4-10] Larsen PO (September 1992). "[The Danish fund for basic research--a new cigar-box]". Ugeskrift for Laeger (in Danish). 154 (39): 2657. PMID 1413190.

[Cambridge1-11] Duncan SH, Leitch EC, Stanley KN, et al. (May 2004). "Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves". The British Journal of Nutrition. 91 (5): 749–55. doi:10.1079/BJN20041101. PMID 15137927.