RAB11FIP1

RAB11FIP1
Identifiers
Aliases	RAB11FIP1, NOEL1A, RCP, rab11-FIP1, RAB11 family interacting protein 1
External IDs	OMIM: 608737; MGI: 1923017; GeneCards: RAB11FIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D0G
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,899,497 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,664,674 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; amniotic fluid; ; bronchial epithelial cell; ; oral cavity; ; islet of Langerhans; ; jejunal mucosa; ; mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; nasal epithelium;
	Top expressed in
	granulocyte; ; zygote; ; tail of embryo; ; lip; ; secondary oocyte; ; esophagus; ; primary oocyte; ; morula; ; jejunum; ; stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; recycling endosome; endosome; phagocytic vesicle membrane; membrane; cytoplasmic vesicle; cytosol; intracellular membrane-bounded organelle;
Biological process	protein transport; regulated exocytosis; negative regulation of adiponectin secretion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	80223
	75767
	ENSG00000156675
	ENSMUSG00000031488
	Q6WKZ4
	Q9D620
	NM_025151; NM_001002233; NM_001002814
	NM_001080813; NM_029423
	NP_001002814; NP_079427
	NP_001074282; NP_083699
	Wikidata
View/Edit Human	View/Edit Mouse

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.

Function

Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases. RAB11FIP1 has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the adipocyte. RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.

Interactions

RAB11FIP1 has been shown to interact with RAB11A and RAB4A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156675 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031488 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, et al. (April 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry. 277 (14): 12190–12199. doi:10.1074/jbc.M108665200. PMID 11786538.
1 2 3 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, et al. (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry. 276 (42): 39067–39075. doi:10.1074/jbc.M104831200. PMID 11495908.
1 2 "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".
1 2 Carson BP, Maria Del Bas J, Moreno-Navarrete JM, Fernandez-Real JM, Mora S (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9) e74687. doi:10.1371/journal.pone.0074687. PMC 3770573. PMID 24040321.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2002). "The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities". Biochemical and Biophysical Research Communications. 292 (4): 909–915. doi:10.1006/bbrc.2002.6736. PMID 11944901.
Thériault C, Rochdi MD, Parent JL (2004). "Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta)". Biochemistry. 43 (19): 5600–5607. doi:10.1021/bi036268v. PMID 15134434.
Peden AA, Schonteich E, Chun J, Junutula JR, Scheller RH, Prekeris R (August 2004). "The RCP-Rab11 complex regulates endocytic protein sorting". Molecular Biology of the Cell. 15 (8): 3530–3541. doi:10.1091/mbc.E03-12-0918. PMC 491816. PMID 15181150.
Lindsay AJ, McCaffrey MW (2004). "Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis". FEBS Letters. 571 (1–3): 86–92. doi:10.1016/j.febslet.2004.06.068. PMID 15280022. S2CID 35306314.
Damiani MT, Pavarotti M, Leiva N, Lindsay AJ, McCaffrey MW, Colombo MI (October 2004). "Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment". Traffic. 5 (10). Copenhagen, Denmark: 785–797. doi:10.1111/j.1600-0854.2004.00220.x. PMID 15355514. S2CID 37310957.
Marie N, Lindsay AJ, McCaffrey MW (2005). "Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner". The Biochemical Journal. 389 (Pt 1): 223–231. doi:10.1042/BJ20042116. PMC 1184555. PMID 15769254.
Tajika Y, Matsuzaki T, Suzuki T, Ablimit A, Aoki T, Hagiwara H, et al. (July 2005). "Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments". Histochemistry and Cell Biology. 124 (1): 1–12. doi:10.1007/s00418-005-0010-3. PMID 16049696. S2CID 14746792.
Patil VS, Sachdeva G, Modi DN, Katkam RR, Manjramkar DD, Hinduja I, et al. (October 2005). "Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium". Journal of Molecular Endocrinology. 35 (2): 357–372. doi:10.1677/jme.1.01807. PMID 16216915.
Jin M, Goldenring JR (2006). "The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system". Biochimica et Biophysica Acta. 1759 (6): 281–295. doi:10.1016/j.bbaexp.2006.06.001. PMID 16920206.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156675 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031488 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lindsay_2002-5] 1 2 3 Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, et al. (April 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry. 277 (14): 12190–12199. doi:10.1074/jbc.M108665200. PMID 11786538.

[Hales_2001-6] 1 2 3 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, et al. (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry. 276 (42): 39067–39075. doi:10.1074/jbc.M104831200. PMID 11495908.

[entrez-7] 1 2 "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".

[ncbi.nlm.nih.gov-8] 1 2 Carson BP, Maria Del Bas J, Moreno-Navarrete JM, Fernandez-Real JM, Mora S (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9) e74687. doi:10.1371/journal.pone.0074687. PMC 3770573. PMID 24040321.

[Ewing_2007-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

RAB11FIP1

Function

Interactions

References

Further reading