RAB11FIP4

RAB11FIP4

Identifiers

RAB11FIP4, RAB11-FIP4, RAB11 family interacting protein 4, FIP4-Rab11

External IDs

OMIM: 611999; MGI: 2442920; GeneCards: RAB11FIP4

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q11.2	Start	31,391,675 bp
Band	17q11.2	End	31,538,211 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11 B5\|11 46.88 cM	Start	79,482,038 bp
Band	11 B5\|11 46.88 cM	End	79,588,849 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

prefrontal cortex

left testis

right testis

corpus callosum

C1 segment

putamen

right frontal lobe

postcentral gyrus

Brodmann area 46

dorsolateral prefrontal cortex

Top expressed in

superior colliculus

visual cortex

dentate gyrus of hippocampal formation granule cell

medial dorsal nucleus

primary visual cortex

primary motor cortex

superior frontal gyrus

olfactory tubercle

piriform cortex

medial geniculate nucleus

More reference expression data


More reference expression data

Gene ontology
Molecular function	calcium ion binding protein homodimerization activity metal ion binding protein binding
Cellular component	cytoplasm endosome membrane endocytic vesicle spindle microtubule organizing center recycling endosome membrane midbody perinuclear region of cytoplasm cleavage furrow cytoskeleton cytoplasmic vesicle extracellular space intracellular membrane-bounded organelle centrosome
Biological process	positive regulation of G1 to G0 transition cytokinesis viral process neural retina development transport endocytic recycling regulation of cytokinesis
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


84440


268451


ENSG00000131242


ENSMUSG00000017639


Q86YS3


Q8BQP8

RefSeq (mRNA)


NM_001303542 NM_001346747 NM_001346748 NM_001346749 NM_032932


NM_175543

RefSeq (protein)


NP_001290471 NP_001333676 NP_001333677 NP_001333678 NP_116321


NP_780752

Location (UCSC)

Chr 17: 31.39 – 31.54 Mb

Chr 11: 79.48 – 79.59 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Rab11 family-interacting protein 4 is a protein that in humans is encoded by the RAB11FIP4 gene.

Interactions

RAB11FIP4 has been shown to interact with RAB11A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131242 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017639 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
↑ Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Hameister H, Kehrer-Sawatzki H (Aug 2001). "Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions". Am J Hum Genet. 69 (3): 516–527. doi:10.1086/323043. PMC 1235482. PMID 11468690.
↑ "Entrez Gene: RAB11FIP4 RAB11 family interacting protein 4 (class II)".
↑ Wallace, Deborah M E; Lindsay Andrew J; Hendrick Alan G; McCaffrey Mary W (Dec 2002). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5). United States: 770–779. doi:10.1016/S0006-291X(02)02720-1. ISSN 0006-291X. PMID 12470645.

Further reading

Jenne DE, Tinschert S, Stegmann E, et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–97. doi:10.1006/geno.2000.6179. PMID 10843809.
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–779. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jenne DE, Tinschert S, Dorschner MO, et al. (2003). "Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse". Genes Chromosomes Cancer. 37 (2): 111–120. doi:10.1002/gcc.10206. PMID 12696059. S2CID 37232718.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fielding AB, Schonteich E, Matheson J, et al. (2006). "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis". EMBO J. 24 (19): 3389–3399. doi:10.1038/sj.emboj.7600803. PMC 1276165. PMID 16148947.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–965. doi:10.1038/ng2083. hdl:2381/22044. PMID 17632510. S2CID 35797973.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.