RAB22A

RAB22A
Identifiers
Aliases	RAB22A, member RAS oncogene family
External IDs	OMIM: 612966; MGI: 105072; GeneCards: RAB22A
Enzyme activity
Gene location (Human)
Chr.	Chromosome 20 (human)
End	58,367,507 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,549,136 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; frontal pole; ; Brodmann area 10; ; Brodmann area 23; ; Brodmann area 46; ; middle frontal gyrus; ; oocyte; ; secondary oocyte; ; tendon of biceps brachii; ; orbitofrontal cortex;
	Top expressed in
	interventricular septum; ; aortic valve; ; ascending aorta; ; cumulus cell; ; otic vesicle; ; right ventricle; ; internal carotid artery; ; temporal muscle; ; saccule; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GDP binding; GTP binding; protein binding; GTPase activity;
Cellular component	endosome; late endosome; phagocytic vesicle membrane; cell projection; membrane; ruffle; plasma membrane; early endosome; phagocytic vesicle; actin cytoskeleton; endosome membrane; extracellular exosome; cytoplasmic vesicle;
Biological process	endosome organization; regulation of vesicle size; protein transport; transport; endocytosis; intracellular protein transport; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57403
	19334
	ENSG00000124209
	ENSMUSG00000027519
	Q9UL26
	P35285
	NM_020673
	NM_024436
	NP_065724
	NP_077756
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124209 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027519 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni C (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Opdam FJ, Kamps G, Croes H, Van Bokhoven H, Ginsel LA, Fransen JA (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–871. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, Stenmark H, Olkkonen VM (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell Sci. 115 (Pt 5): 899–911. doi:10.1242/jcs.115.5.899. PMID 11870209.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi:10.1074/jbc.M311228200. PMID 14613930.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell. 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC 491835. PMID 15181155.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mesa R, Magadán J, Barbieri A, López C, Stahl PD, Mayorga LS (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Magadán JG, Barbieri MA, Mesa R, Stahl PD, Mayorga LS (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC 1430328. PMID 16537905.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124209 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027519 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: RAB22A RAB22A, member RAS oncogene family".

RAB22A

References

Further reading