RAB25

RAB25
Identifiers
Aliases	RAB25, CATX-8, RAB11C, member RAS oncogene family
External IDs	OMIM: 612942; MGI: 1858203; GeneCards: RAB25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OIL, 3TSO
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,070,504 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,455,607 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; gums; ; mucosa of pharynx; ; gingival epithelium; ; skin of thigh; ; oral cavity; ; rectum; ; human penis;
	Top expressed in
	transitional epithelium of urinary bladder; ; lip; ; esophagus; ; epithelium of stomach; ; left colon; ; skin of external ear; ; mucous cell of stomach; ; cervix; ; pyloric antrum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; myosin V binding; protein binding; GTPase activity;
Cellular component	pseudopodium membrane; plasma membrane; cell projection; pseudopodium; extracellular exosome; cytoplasmic vesicle; membrane; endosome; recycling endosome;
Biological process	protein transport; regulation of vesicle-mediated transport; positive regulation of epithelial cell migration; epithelial cell morphogenesis; positive regulation of cell population proliferation; pseudopodium organization; transport; intracellular protein transport; exocytosis; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57111
	53868
	ENSG00000132698
	ENSMUSG00000008601
	P57735
	Q9WTL2
	NM_020387
	NM_016899
	NP_065120
	NP_058595
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. It is thought to act as a promoter of tumor development.

Interactions

RAB25 has been shown to interact with RAB11FIP2 and RAB11FIP5.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132698 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008601 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". Journal of Molecular Biology. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
↑ "Entrez Gene: RAB25 RAB25, member RAS oncogene family".
↑ Kessler D, Gruen GC, Heider D, Morgner J, Reis H, Schmid KW, et al. (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–656. doi:10.1159/000295249. PMID 22613965.
1 2 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, et al. (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry. 276 (42): 39067–39075. doi:10.1074/jbc.M104831200. PMID 11495908.
1 2 Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". The Journal of Biological Chemistry. 276 (42): 38966–38970. doi:10.1074/jbc.M106133200. PMID 11481332.

Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung". The Journal of Biological Chemistry. 268 (25): 18419–18422. doi:10.1016/S0021-9258(17)46639-7. PMID 8360141.
Ray GS, Lee JR, Nwokeji K, Mills LR, Goldenring JR (November 1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia". Laboratory Investigation; A Journal of Technical Methods and Pathology. 77 (5): 503–511. PMID 9389793.
Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, et al. (June 2001). "Myosin vb is associated with plasma membrane recycling systems". Molecular Biology of the Cell. 12 (6): 1843–1857. doi:10.1091/mbc.12.6.1843. PMC 37346. PMID 11408590.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, et al. (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–1765. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715). New York, N.Y.: 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo". Pathology. 38 (6): 561–567. doi:10.1080/00313020601024037. PMID 17393986. S2CID 85960469.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132698 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008601 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Pereira-Leal_2001-5] Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". Journal of Molecular Biology. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.

[entrez-6] "Entrez Gene: RAB25 RAB25, member RAS oncogene family".

[7] Kessler D, Gruen GC, Heider D, Morgner J, Reis H, Schmid KW, et al. (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–656. doi:10.1159/000295249. PMID 22613965.

[Hales_2001-8] 1 2 Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, et al. (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry. 276 (42): 39067–39075. doi:10.1074/jbc.M104831200. PMID 11495908.

[Prekeris_2001-9] 1 2 Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". The Journal of Biological Chemistry. 276 (42): 38966–38970. doi:10.1074/jbc.M106133200. PMID 11481332.

RAB25

Interactions

References

Further reading