RAB3C

RAB3C

Identifiers

RAB3C, member RAS oncogene family

External IDs

OMIM: 612829; MGI: 1914545; GeneCards: RAB3C

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.6.5.2	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 5 (human)

Band	5q11.2	Start	58,582,221 bp
Band	5q11.2	End	58,859,394 bp

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)

Band	13\|13 D2.1	Start	110,190,721 bp
Band	13\|13 D2.1	End	110,417,530 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

lateral nuclear group of thalamus

pars compacta

pars reticulata

Brodmann area 46

middle temporal gyrus

superior frontal gyrus

Brodmann area 23

superior vestibular nucleus

islet of Langerhans

postcentral gyrus

Top expressed in

medial dorsal nucleus

ventral tegmental area

medial geniculate nucleus

subiculum

lateral geniculate nucleus

superior colliculus

dorsomedial hypothalamic nucleus

paraventricular nucleus of hypothalamus

dorsal tegmental nucleus

anterior amygdaloid area

More reference expression data

n/a

Gene ontology
Molecular function	nucleotide binding GTP binding myosin V binding protein binding GTP-dependent protein binding GTPase activity
Cellular component	perinuclear region of cytoplasm vesicle cytosol plasma membrane membrane synaptic vesicle anchored component of synaptic vesicle membrane endosome
Biological process	regulation of exocytosis protein transport antigen processing and presentation intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


115827


67295


ENSG00000152932


ENSMUSG00000021700


Q96E17


P62823

RefSeq (mRNA)


NM_138453 NM_001317915


NM_023852 NM_001360099

RefSeq (protein)


NP_001304844 NP_612462


NP_076341 NP_001347028

Location (UCSC)

Chr 5: 58.58 – 58.86 Mb

Chr 13: 110.19 – 110.42 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.

Interactions

Rab3C has been shown to interact with ZWINT.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152932 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021700 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.
↑ "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".
↑ van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.

Further reading

Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (Jun 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Schlüter OM, Khvotchev M, Jahn R, Südhof TC (Oct 2002). "Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion". The Journal of Biological Chemistry. 277 (43): 40919–29. doi:10.1074/jbc.M203704200. PMID 12167638.
Uphues I, Chern Y, Eckel J (Dec 1995). "Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats". FEBS Letters. 377 (2): 109–12. doi:10.1016/0014-5793(95)01315-6. PMID 8543030. S2CID 27119138.

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