RAB6C

RAB6C

Identifiers

RAB6C, WTH3, member RAS oncogene family

External IDs

OMIM: 612909; GeneCards: RAB6C

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.6.5.2	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q21.1	Start	129,979,666 bp
Band	2q21.1	End	129,982,738 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

endometrium

primary visual cortex

superior frontal gyrus

prefrontal cortex

hippocampus proper

Brodmann area 9

corpus callosum

putamen

gonad

n/a

More reference expression data

n/a

Gene ontology
Molecular function	nucleotide binding GTP binding GTPase activity
Cellular component	cytoplasm centrosome intracellular anatomical structure cytoskeleton nucleus microtubule organizing center cytosol Golgi apparatus
Biological process	regulation of centrosome duplication retrograde transport, endosome to Golgi intra-Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum mitotic cell cycle small GTPase mediated signal transduction intracellular protein transport Rab protein signal transduction
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


84084


n/a


ENSG00000222014


n/a


Q9H0N0


n/a

RefSeq (mRNA)


NM_032144


n/a

RefSeq (protein)


NP_115520


n/a

Location (UCSC)

Chr 2: 129.98 – 129.98 Mb

n/a

PubMed search

n/a

View/Edit Human

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000222014 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, et al. (December 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.
↑ Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". British Journal of Cancer. 96 (10): 1579–1586. doi:10.1038/sj.bjc.6603724. PMC 2359938. PMID 17426708.
↑ "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

Further reading

Fitzgerald ML, Reed GL (September 1999). "Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution". The Biochemical Journal. 342 (Pt 2): 353–360. doi:10.1042/0264-6021:3420353. PMC 1220472. PMID 10455022.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Shan J, Yuan L, Budman DR, Xu HP (April 2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochimica et Biophysica Acta. 1589 (2): 112–123. doi:10.1016/S0167-4889(02)00164-7. PMID 12007787.
Tian K, Jurukovski V, Wang XP, Kaplan MH, Xu H (November 2005). "Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells". Cancer Research. 65 (21): 10024–10031. doi:10.1158/0008-5472.CAN-05-1944. PMID 16267028.

v t e PDB gallery
1yzq: GppNHp-Bound Rab6 GTPase 2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.