RADIL

RADIL

Identifiers

RADIL, RASIP2, Rap associating with DIL domain

External IDs

OMIM: 611491; MGI: 2443088; GeneCards: RADIL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1UM1, 3EC8

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7p22.1	Start	4,797,055 bp
Band	7p22.1	End	4,883,716 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 G2	Start	142,470,594 bp
Band	5\|5 G2	End	142,536,853 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

cerebellar vermis

gonad

right hemisphere of cerebellum

right testis

left testis

pons

tibial nerve

sural nerve

Top expressed in

habenula

seminiferous tubule

spermatocyte

cerebellar cortex

superior cervical ganglion

atrium

dorsomedial hypothalamic nucleus

superior frontal gyrus

lobe of cerebellum

lateral septal nucleus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	microtubule protein-containing complex
Biological process	multicellular organism development substrate adhesion-dependent cell spreading cell adhesion signal transduction
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55698


231858


ENSG00000157927


ENSMUSG00000029576


Q96JH8


Q69Z89

RefSeq (mRNA)


NM_018059


NM_001289588 NM_178702 NM_001310752

RefSeq (protein)


NP_060529


NP_001276517 NP_001297681 NP_848817

Location (UCSC)

Chr 7: 4.8 – 4.88 Mb

Chr 5: 142.47 – 142.54 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Ras-associating and dilute domain-containing protein is a protein that in humans is encoded by the RADIL gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157927 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029576 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang Z, Rehmann H, Price LS, Riedl J, Bos JL (Sep 2005). "AF6 negatively regulates Rap1-induced cell adhesion". J Biol Chem. 280 (39): 33200–5. doi:10.1074/jbc.M505057200. PMID 16051602.
↑ Smolen GA, Schott BJ, Stewart RA, Diederichs S, Muir B, Provencher HL, Look AT, Sgroi DC, Peterson RT, Haber DA (Sep 2007). "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors". Genes Dev. 21 (17): 2131–6. doi:10.1101/gad.1561507. PMC 1950852. PMID 17704304.
↑ "Entrez Gene: FLJ10324 hypothetical protein FLJ10324".

Further reading

Ahmed SM, Daulat AM, Meunier A, Angers S (February 2010). "G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil". J. Biol. Chem. 285 (9): 6538–51. doi:10.1074/jbc.M109.069948. PMC 2825450. PMID 20048162.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

v t e PDB gallery
1um1: Solution Structure of RSGI RUH-007, PDZ domain in Human cDNA

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