RAET1G

RAET1G
Identifiers
Aliases	RAET1G, ULBP5, retinoic acid early transcript 1G
External IDs	OMIM: 609244; GeneCards: RAET1G
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,923,121 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; left adrenal gland; ; right adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; vagina; ; stromal cell of endometrium; ; olfactory zone of nasal mucosa; ; ectocervix; ; skin of abdomen;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding; protein binding;
Cellular component	integral component of membrane; anchored component of membrane; endoplasmic reticulum; membrane; extracellular region; plasma membrane; extracellular space; external side of plasma membrane;
Biological process	natural killer cell mediated cytotoxicity; immune system process; viral process; positive regulation of natural killer cell cytokine production; T cell mediated cytotoxicity; immune response; natural killer cell activation; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	353091
	n/a
	ENSG00000203722
	n/a
	Q6H3X3
	n/a
	NM_001001788
	n/a
	NP_001001788
	n/a
	Wikidata
View/Edit Human

Retinoic acid early transcript 1G (RAET1G) is a cell surface glycoprotein encoded by RAET1G gene located on chromosome 6. RAET1G is related to MHC class I molecules, but its gene maps outside the MHC locus. RAET1G is composed of an external α1α2 domain, a transmembrane segment, and C-terminal cytoplasmic tail. RAET1E functions as a stress-induced ligand for NKG2D receptors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000203722 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, et al. (January 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–123. doi:10.1006/geno.2001.6673. PMID 11827464.
1 2 Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (July 2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D". Journal of Immunology. 173 (2). Baltimore: 1078–1084. doi:10.4049/jimmunol.173.2.1078. PMID 15240696.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000203722 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Radosavljevic_2002-3] 1 2 3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, et al. (January 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–123. doi:10.1006/geno.2001.6673. PMID 11827464.

[Bacon_2004-4] 1 2 Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (July 2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D". Journal of Immunology. 173 (2). Baltimore: 1078–1084. doi:10.4049/jimmunol.173.2.1078. PMID 15240696.