RAET1L

RAET1L
Identifiers
Aliases	RAET1L, ULBP6, retinoic acid early transcript 1L, RAET1H
External IDs	OMIM: 611047; GeneCards: RAET1L
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4S0U
Gene location (Human)
Chr.	Chromosome 6 (human)
End	150,025,532 bp
RNA expression pattern
	Top expressed in
	vagina; ; skin of leg; ; skin of abdomen; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; islet of Langerhans; ; tonsil; ; ectocervix; ; stromal cell of endometrium; ; smooth muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding; protein binding;
Cellular component	anchored component of membrane; membrane; extracellular region; plasma membrane; endoplasmic reticulum; extracellular space; external side of plasma membrane;
Biological process	natural killer cell mediated cytotoxicity; immune system process; viral process; T cell mediated cytotoxicity; immune response; natural killer cell activation; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	154064
	n/a
	ENSG00000155918
	n/a
	Q5VY80
	n/a
	NM_130900
	n/a
	NP_570970
	n/a
	Wikidata
View/Edit Human

Retinoic acid early transcript 1L (RAET1L) is a cell surface glycoprotein encoded by RAET1L gene located on the chromosome 6. RAET1L is related to MHC class I molecules, but its gene maps outside the MHC locus. RAET1L is composed of the α1α2 domain and is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor. Its expression is, for example, triggered in course of HCMV infection, but HCMV alters its function. HCMV-encoded UL16 glycoprotein retains ULBP6 inside the cells, preventing it from reaching the cell surface and being exposed to cells of the immune system.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155918 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, et al. (January 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–123. doi:10.1006/geno.2001.6673. PMID 11827464.
1 2 3 4 Eagle RA, Traherne JA, Hair JR, Jafferji I, Trowsdale J (November 2009). "ULBP6/RAET1L is an additional human NKG2D ligand". European Journal of Immunology. 39 (11): 3207–3216. doi:10.1002/eji.200939502. PMID 19658097.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155918 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Radosavljevic_2002-3] 1 2 3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, et al. (January 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–123. doi:10.1006/geno.2001.6673. PMID 11827464.

[Eagle_2009-4] 1 2 3 4 Eagle RA, Traherne JA, Hair JR, Jafferji I, Trowsdale J (November 2009). "ULBP6/RAET1L is an additional human NKG2D ligand". European Journal of Immunology. 39 (11): 3207–3216. doi:10.1002/eji.200939502. PMID 19658097.