RASA4

RASA4
Identifiers
Aliases	RASA4, CAPRI, GAPL, RAS p21 protein activator 4
External IDs	OMIM: 607943; MGI: 1858600; GeneCards: RASA4
Gene location (Human)
Chr.	Chromosome 7 (human)
End	102,616,756 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,111,860 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; sural nerve; ; right coronary artery; ; granulocyte; ; myometrium; ; body of uterus; ; subcutaneous adipose tissue; ; canal of the cervix;
	Top expressed in
	primary oocyte; ; Ileal epithelium; ; zygote; ; muscle of thigh; ; secondary oocyte; ; plantaris muscle; ; neural layer of retina; ; extensor digitorum longus muscle; ; stroma of bone marrow; ; ankle joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; metal ion binding; phospholipid binding;
Cellular component	cytoplasm; cytosol; membrane; intrinsic component of the cytoplasmic side of the plasma membrane; plasma membrane;
Biological process	intracellular signal transduction; regulation of GTPase activity; MAPK cascade; negative regulation of GTPase activity; signal transduction; positive regulation of GTPase activity; negative regulation of Ras protein signal transduction; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10156
	54153
	ENSG00000105808
	ENSMUSG00000004952
	O43374
	Q6PFQ7
	NM_001079877; NM_006989
	NM_001039103; NM_133914
	NP_001073346; NP_008920
	NP_001034192; NP_598675
	Wikidata
View/Edit Human	View/Edit Mouse

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105808 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004952 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776. S2CID 18141962.
1 2 "Entrez Gene: RASA4 RAS p21 protein activator 4".

External links

RASA4 human gene location in the UCSC Genome Browser.
RASA4 human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105808 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004952 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11448776-5] Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776. S2CID 18141962.

[entrez-6] 1 2 "Entrez Gene: RASA4 RAS p21 protein activator 4".

RASA4

References

Further reading

External links