RBM3

RBM3
Identifiers
Aliases	RBM3, IS1-RNPL, RNPL, RNA binding motif (RNP1, RRM) protein 3, RNA binding motif protein 3
External IDs	OMIM: 300027; MGI: 3642874; GeneCards: RBM3
Gene location (Human)
Chr.	X chromosome (human)
End	48,581,162 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; human penis; ; monocyte; ; synovial joint; ; nipple; ; gastric mucosa; ; saphenous vein; ; skin of leg; ; body of pancreas; ; olfactory zone of nasal mucosa;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; mRNA 3'-UTR binding; poly(U) RNA binding; translation repressor activity; ribosomal large subunit binding; small ribosomal subunit rRNA binding;
Cellular component	cytoplasm; large ribosomal subunit; dendrite; cell projection; nucleolus; nucleus; nucleoplasm; spliceosomal complex; ribonucleoprotein complex;
Biological process	RNA processing; regulation of translation; positive regulation of translation; response to cold; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5935
	100043257
	ENSG00000102317
	n/a
	P98179
	n/a
	NM_001017430; NM_001017431; NM_006743
	XM_036156140
	NP_006734
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.

Gene

A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. RBM3 contains a poison exon whose inclusion is lowered during hypothermia.

Structure

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain.

Function

Expression of this gene is induced by cold shock and low oxygen tension.

RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects. According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues and based on confocal microscopy mainly localised to the nucleoplasm.

Clinical significance

RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker. Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102317 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–2311. doi:10.1093/hmg/4.12.2307. PMID 8634703.
1 2 "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".
↑ Lin JQ, Khuperkar D, Pavlou S, Makarchuk S, Patikas N, Lee FC, et al. (July 2023). "HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion". The EMBO Journal. 42 (14) e113168. doi:10.15252/embj.2022113168. PMC 10350819. PMID 37248947.
1 2 Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.
↑ "Tissue expression of RBM3 - Summary". The Human Protein Atlas.
↑ "Cell atlas - RBM3". The Human Protein Atlas.
↑ "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.

Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, et al. (July 1997). "Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress". Biochemical and Biophysical Research Communications. 236 (3): 804–807. Bibcode:1997BBRC..236..804D. doi:10.1006/bbrc.1997.7059. PMID 9245737.
Chappell SA, Mauro VP (September 2003). "The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements". The Journal of Biological Chemistry. 278 (36): 33793–33800. doi:10.1074/jbc.M303495200. PMID 12824175.
Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, et al. (April 2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". Journal of Cell Science. 117 (Pt 9): 1785–1794. doi:10.1242/jcs.01026. PMID 15075239.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–2772. Bibcode:2004AnaCh..76.2763B. doi:10.1021/ac035352d. PMID 15144186.
Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). "Protein interactions among the vaccinia virus late transcription factors". Virology. 329 (2): 328–336. doi:10.1016/j.virol.2004.08.017. hdl:10161/15063. PMID 15518812.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, et al. (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–126. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.
Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, et al. (April 2006). "Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer". Journal of Cellular Biochemistry. 97 (6): 1275–1282. doi:10.1002/jcb.20725. PMID 16552754. S2CID 9804734.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102317 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Derry_1995-4] Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–2311. doi:10.1093/hmg/4.12.2307. PMID 8634703.

[entrez-5] 1 2 "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".

[6] Lin JQ, Khuperkar D, Pavlou S, Makarchuk S, Patikas N, Lee FC, et al. (July 2023). "HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion". The EMBO Journal. 42 (14) e113168. doi:10.15252/embj.2022113168. PMC 10350819. PMID 37248947.

[Zhou_2017-7] 1 2 Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.

[8] "Tissue expression of RBM3 - Summary". The Human Protein Atlas.

[9] "Cell atlas - RBM3". The Human Protein Atlas.

[10] "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.