RCBTB2

RCBTB2
Identifiers
Aliases	RCBTB2, CHC1L, RLG, RCC1 and BTB domain containing protein 2
External IDs	OMIM: 603524; MGI: 1917200; GeneCards: RCBTB2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	48,533,256 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	73,445,283 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; monocyte; ; optic nerve; ; parietal pleura; ; visceral pleura; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; seminal vesicula; ; ganglionic eminence; ; ventricular zone;
	Top expressed in
	otic vesicle; ; saccule; ; otic placode; ; mandibular prominence; ; thymus; ; maxillary prominence; ; somite; ; ventricular zone; ; brown adipose tissue; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	acrosomal vesicle; cytoplasmic vesicle;
Biological process	regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1102
	105670
	ENSG00000136161
	ENSMUSG00000022106
	O95199
	Q99LJ7
NM_001268; NM_001286830; NM_001286831; NM_001286832; NM_001352424;
	NM_001352425; NM_001352426; NM_001352427; NM_001352428; NM_001352429; NM_001352430; NM_001352431
	NM_001170694; NM_134083
NP_001259; NP_001273759; NP_001273760; NP_001273761; NP_001339353;
	NP_001339354; NP_001339355; NP_001339356; NP_001339357; NP_001339358; NP_001339359; NP_001339360
	NP_001164165; NP_598844
	Wikidata
View/Edit Human	View/Edit Mouse

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136161 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022106 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.
1 2 "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Latil A, Morant P, Fournier G, Mangin P, Berthon P, Cussenot O (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer. 99 (5): 689–96. doi:10.1002/ijc.10393. PMID 12115502. S2CID 36595791.
Renault L, Nassar N, Wittinghofer A, Roth M, Vetter IR (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D. 55 (Pt 1): 272–5. Bibcode:1999AcCrD..55..272R. doi:10.1107/S0907444998007768. PMID 10089422.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136161 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022106 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806834-5] Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.

[entrez-6] 1 2 "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".

RCBTB2

References

Further reading