RGC100

RGC100 is an immune stimulant drug. It is a double-stranded RNA molecule of 100 G:C base pairs, with a molecular weight of 64.9 KDa. It activates dendritic cells of the human immune system by specifically targeting endosomal TLR3, while mostly avoiding MDA5. It has good solubility and serum stability.

References

↑ Naumann, Kai; Wehner, Rebekka; Schwarze, Anett; Petzold, Christiane; Schmitz, Marc; Rohayem, Jacques (2013). "Activation of Dendritic Cells by the Novel Toll-Like Receptor 3 Agonist RGC100". Clinical and Developmental Immunology. 2013 283649. doi:10.1155/2013/283649. PMC 3878805. PMID 24454470.

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[1] Naumann, Kai; Wehner, Rebekka; Schwarze, Anett; Petzold, Christiane; Schmitz, Marc; Rohayem, Jacques (2013). "Activation of Dendritic Cells by the Novel Toll-Like Receptor 3 Agonist RGC100". Clinical and Developmental Immunology. 2013 283649. doi:10.1155/2013/283649. PMC 3878805. PMID 24454470.