RGS11

RGS11

Identifiers

RGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11

External IDs

OMIM: 603895; MGI: 1354739; GeneCards: RGS11

Gene location (Human)

Chr.	Chromosome 16 (human)

Band	16p13.3	Start	268,301 bp
Band	16p13.3	End	275,980 bp

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)

Band	17\|17 A3.3	Start	26,421,925 bp
Band	17\|17 A3.3	End	26,430,298 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

right frontal lobe

anterior pituitary

C1 segment

cingulate gyrus

anterior cingulate cortex

tibial nerve

amygdala

Brodmann area 9

apex of heart

Top expressed in

neural layer of retina

superior frontal gyrus

morula

primary visual cortex

islet of Langerhans

adrenal gland

ganglion of vagus nerve

autonomic nerve plexus

CA3 field

stomach

More reference expression data


More reference expression data

Gene ontology
Molecular function	G-protein beta-subunit binding GTPase activator activity GTPase activity
Cellular component	cytoplasm plasma membrane protein-containing complex intracellular anatomical structure
Biological process	G protein-coupled receptor signaling pathway negative regulation of signal transduction intracellular signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


8786


50782


ENSG00000076344


ENSMUSG00000024186


O94810


Q9Z2H1

RefSeq (mRNA)


NM_001286485 NM_001286486 NM_003834 NM_183337


NM_001081069

RefSeq (protein)


NP_001273414 NP_001273415 NP_003825 NP_899180


NP_001074538

Location (UCSC)

Chr 16: 0.27 – 0.28 Mb

Chr 17: 26.42 – 26.43 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000076344 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024186 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
1 2 "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading

Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553. S2CID 4362044.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain". J. Neurosci. 17 (20): 8024–37. doi:10.1523/JNEUROSCI.17-20-08024.1997. PMC 6793903. PMID 9315921.

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