RHOBTB1

RHOBTB1
Identifiers
Aliases	RHOBTB1, Rho related BTB domain containing 1
External IDs	OMIM: 607351; MGI: 1916538; GeneCards: RHOBTB1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	61,001,440 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	69,127,621 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; Achilles tendon; ; muscle of thigh; ; biceps brachii; ; right uterine tube; ; placenta; ; Skeletal muscle tissue of biceps brachii; ; cardia; ; glutes;
	Top expressed in
	myocardium of ventricle; ; internal carotid artery; ; cumulus cell; ; aortic valve; ; ascending aorta; ; external carotid artery; ; ureter; ; islet of Langerhans; ; otolith organ; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; GTPase activity; protein kinase binding;
Cellular component	cytosol; plasma membrane; intracellular anatomical structure; cytoplasm; cytoskeleton; cell projection;
Biological process	regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; cell morphogenesis; actin filament organization; Rho protein signal transduction; cell migration; actin cytoskeleton organization; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; engulfment of apoptotic cell;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9886
	69288
	ENSG00000072422
	ENSMUSG00000019944
	O94844
	Q9DAK3
NM_001242359; NM_014836; NM_001350902; NM_001350903; NM_001350904;
	NM_001350905; NM_001350906; NM_001350907; NM_001350908; NM_001350909; NM_001350910; NM_001350911
	NM_001081347; NM_001252636; NM_001252637; NM_001252638
NP_001229288; NP_055651; NP_001337831; NP_001337832; NP_001337833;
	NP_001337834; NP_001337835; NP_001337836; NP_001337837; NP_001337838; NP_001337839; NP_001337840; NP_001229288.1; NP_055651.1
	NP_001074816; NP_001239565; NP_001239566; NP_001239567
	Wikidata
View/Edit Human	View/Edit Mouse

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.

The protein encoded by this gene belongs to the Rho family, which is part of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, two tandem BTB (broad complex, tramtrack, and bric-à-brac) domains, and a conserved C-terminal region. This protein plays a role in small GTPase-mediated signal transduction and in the organization of the actin filament system. Alternative transcriptional splice variants of this gene have been characterized.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000072422 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019944 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.
1 2 "Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1".

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. CiteSeerX 10.1.1.529.4378. doi:10.1093/dnares/5.5.277. PMID 9872452. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Ramos S, Khademi F, Somesh BP, Rivero F (2003). "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse". Gene. 298 (2): 147–57. doi:10.1016/S0378-1119(02)00980-0. PMID 12426103.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Aspenström P, Fransson A, Saras J (2004). "Rho GTPases have diverse effects on the organization of the actin filament system". Biochem. J. 377 (Pt 2): 327–37. doi:10.1042/BJ20031041. PMC 1223866. PMID 14521508.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beder LB, Gunduz M, Ouchida M, et al. (2006). "Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer" (PDF). J. Cancer Res. Clin. Oncol. 132 (1): 19–27. doi:10.1007/s00432-005-0033-0. PMID 16170569. S2CID 35193238.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000072422 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019944 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11222756-5] Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.

[entrez-6] 1 2 "Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1".

RHOBTB1

References

Further reading