RHPN2

RHPN2
Identifiers
Aliases	RHPN2, P76RBE, RHOBP, rhophilin, Rho GTPase binding protein 2, rhophilin Rho GTPase binding protein 2
External IDs	OMIM: 617932; MGI: 1289234; GeneCards: RHPN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VSV
Gene location (Human)
Chr.	Chromosome 19 (human)
End	33,064,888 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	35,091,714 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; pancreatic ductal cell; ; mucosa of ileum; ; oocyte; ; bronchial epithelial cell; ; mucosa of sigmoid colon; ; parotid gland; ; secondary oocyte; ; jejunal mucosa; ; germinal epithelium;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; parotid gland; ; submandibular gland; ; epithelium of stomach; ; lacrimal gland; ; left colon; ; migratory enteric neural crest cell; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	85415
	52428
	ENSG00000131941
	ENSMUSG00000030494
	Q8IUC4
	Q8BWR8
	NM_033103
	NM_027897
	NP_149094
	NP_082173
	Wikidata
View/Edit Human	View/Edit Mouse

Rhophilin-2 is a protein that in humans is encoded by the RHPN2 gene.

Interactions

RHPN2 has been shown to interact with RHOB.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131941 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030494 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD (November 2002). "The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization". J. Biol. Chem. 277 (46): 43924–32. doi:10.1074/jbc.M203569200. PMID 12221077.
↑ "Entrez Gene: RHPN2 rhophilin, Rho GTPase binding protein 2".
↑ Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. hdl:2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51241. PMID 12473120. S2CID 23901713.

Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. hdl:2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51241. PMID 12473120. S2CID 23901713.
Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Steuve S, Devosse T, Lauwers E, Vanderwinden JM, André B, Courtoy PJ, Pirson I (2006). "Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB". Exp. Cell Res. 312 (20): 3981–9. doi:10.1016/j.yexcr.2006.08.028. PMID 17054945.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131941 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030494 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12221077-5] Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD (November 2002). "The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization". J. Biol. Chem. 277 (46): 43924–32. doi:10.1074/jbc.M203569200. PMID 12221077.

[entrez-6] "Entrez Gene: RHPN2 rhophilin, Rho GTPase binding protein 2".

[pmid12473120-7] Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP" (PDF). Eur. J. Biochem. 269 (24): 6241–9. doi:10.1046/j.1432-1033.2002.03343.x. hdl:2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51241. PMID 12473120. S2CID 23901713.

RHPN2

Interactions

References

Further reading