RIMS1

RIMS1
Identifiers
Aliases	RIMS1, CORD7, RAB3IP2, RIM, RIM1, regulating synaptic membrane exocytosis 1
External IDs	OMIM: 606629; MGI: 2152971; GeneCards: RIMS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CSS
RNA expression pattern Bgee Human Mouse (ortholog) n/a n/a BioGPS More reference expression data
Gene ontology Molecular function GTPase regulator activity metal ion binding protein binding transmembrane transporter binding RNA binding Cellular component cytosol membrane plasma membrane synapse presynaptic active zone cell junction presynaptic membrane cytoskeleton of presynaptic active zone presynaptic active zone cytoplasmic component Biological process cell differentiation response to stimulus synaptic vesicle exocytosis positive regulation of inhibitory postsynaptic potential membrane fusion regulation of neurotransmitter secretion secretion glutamate secretion positive regulation of gene expression positive regulation of excitatory postsynaptic potential positive regulation of dendrite extension regulated exocytosis intracellular protein transport neurotransmitter transport neurotransmitter secretion visual perception calcium-ion regulated exocytosis exocytosis regulation of catalytic activity regulation of membrane potential calcium ion-regulated exocytosis of neurotransmitter regulation of synaptic vesicle exocytosis transport regulation of synaptic plasticity positive regulation of synaptic transmission protein-containing complex assembly acrosomal vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 22999 116837 Ensembl ENSG00000079841 ENSMUSG00000041670 UniProt Q86UR5 Q99NE5 RefSeq (mRNA) NM_001168407 NM_001168408 NM_001168409 NM_001168410 NM_001168411 NM_014989 NM_001012623 NM_001012624 NM_001012625 NM_053270 NM_183018 RefSeq (protein) NP_001161879 NP_001161880 NP_001161881 NP_001161882 NP_001161883 NP_055804 NP_001337340 NP_001337341 NP_001337342 NP_001337343 NP_001337344 NP_001337345 NP_001337346 NP_001337347 NP_001337348 NP_001337349 NP_001337350 NP_001337351 NP_001337352 NP_001337353 NP_001337354 NP_001337355 NP_001337356 NP_001337357 NP_001337358 NP_001337359 NP_001337360 NP_001337361 NP_001337362 NP_001337363 NP_001337364 NP_001337365 NP_001337366 NP_001337367 NP_001337368 NP_001337369 NP_001337370 NP_001337371 NP_001337372 NP_001337373 NP_001337374 NP_001337375 NP_001337376 NP_001337377 NP_001337378 NP_001337379 NP_001337381 NP_001337383 NP_001337384 NP_001337385 NP_001337386 NP_001337387 NP_001337388 NP_001337389 NP_001337390 NP_001337391 NP_001337392 NP_001337393 NP_001337394 NP_001337395 NP_001337396 NP_001337397 NP_001337398 NP_001337399 NP_001337400 NP_001337401 NP_001337402 NP_001337403 NP_001012641 NP_001012642 NP_001012643 NP_444500 NP_898839 Location (UCSC) n/a n/a PubMed search
Wikidata
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Regulating synaptic membrane exocytosis protein 1 is a protein that in humans is encoded by the RIMS1 gene.

Function

RAB3A (MIM 179490), a member of the Ras superfamily of genes, is a synaptic vesicle protein that regulates synaptic vesicle exocytosis. MUNC13 (UNC13; MIM 605836) and its isoforms are required for priming synaptic vesicles for exocytosis. The RIM family of active zone proteins likely function as protein scaffolds that help regulate vesicle exocytosis during short-term plasticity.[supplied by OMIM]

Clinical significance

Mutations of the gene cause cone-rod dystrophy 7.

Interactions

RIMS1 has been shown to interact with:

• ERC2,
• RAB3A,
• UNC13A,
• UNC13B, and
• YWHAH.