RINT1

RINT1

Identifiers

RINT1, RINT-1, RAD50 interactor 1, ILFS3

External IDs

OMIM: 610089; MGI: 1916233; GeneCards: RINT1

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q22.3	Start	105,532,169 bp
Band	7q22.3	End	105,567,677 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 A3	Start	23,992,709 bp
Band	5\|5 A3	End	24,025,367 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibia

testicle

body of pancreas

muscle of thigh

gastrocnemius muscle

right uterine tube

Achilles tendon

skin of abdomen

skin of leg

cerebellar hemisphere

Top expressed in

Rostral migratory stream

spermatocyte

tail of embryo

islet of Langerhans

fossa

right kidney

esophagus

genital tubercle

stomach

neural tube

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm Dsl1/NZR complex endoplasmic reticulum membrane endoplasmic reticulum membrane cytosol
Biological process	protein transport cell cycle regulation of ER to Golgi vesicle-mediated transport Golgi vesicle transport vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi organization
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


60561


72772


ENSG00000135249


ENSMUSG00000028999


Q6NUQ1


Q8BZ36

RefSeq (mRNA)


NM_021930 NM_001346599 NM_001346600 NM_001346601 NM_001346603


NM_177323 NM_001310467

RefSeq (protein)


NP_001333528 NP_001333529 NP_001333530 NP_001333532 NP_068749


NP_001297396 NP_796297

Location (UCSC)

Chr 7: 105.53 – 105.57 Mb

Chr 5: 23.99 – 24.03 Mb

PubMed search

View/Edit Human

View/Edit Mouse

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.

Interactions

RINT1 has been shown to interact with Rad50 and ZW10.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135249 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028999 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Xiao J, Liu CC, Chen PL, Lee WH (March 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". The Journal of Biological Chemistry. 276 (9): 6105–6111. doi:10.1074/jbc.M008893200. PMID 11096100.
1 2 Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, et al. (March 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–1278. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
↑ "Entrez Gene: RINT1 RAD50 interactor 1".

Further reading

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, et al. (August 2004). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". The EMBO Journal. 23 (16): 3216–3226. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Molecular Biology of the Cell. 17 (6): 2780–2788. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Molecular Cell. 22 (1): 63–71. doi:10.1016/j.molcel.2006.02.016. PMID 16600870.
Lin X, Liu CC, Gao Q, Zhang X, Wu G, Lee WH (July 2007). "RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival". Molecular and Cellular Biology. 27 (13): 4905–4916. doi:10.1128/MCB.02396-06. PMC 1951495. PMID 17470549.
Sun Y, Shestakova A, Hunt L, Sehgal S, Lupashin V, Storrie B (October 2007). "Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis". Molecular Biology of the Cell. 18 (10): 4129–4142. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596.

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